Satarkar Nitin S, Zach Hilt J
Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA.
Acta Biomater. 2008 Jan;4(1):11-6. doi: 10.1016/j.actbio.2007.07.009. Epub 2007 Aug 3.
Nanocomposite hydrogels are a new class of intelligent materials which have recently attracted interest as biomaterials. In this study, magnetic nanocomposites of temperature-sensitive hydrogels have been developed and demonstrated to be responsive to alternating magnetic fields. Nanocomposites were synthesized by incorporation of superparamagnetic Fe(3)O(4) particles in negative temperature-sensitive poly(N-isopropylacrylamide) hydrogels. The systems were characterized for temperature-responsive swelling, remote heating on application of an alternating magnetic field and remote-controlled drug delivery applications. The rise in temperature in external alternating magnetic field depends on the Fe(3)O(4) particle loading of the system. Preliminary studies on remote-controlled drug release showed reduced release in the presence of an alternating magnetic field.
纳米复合水凝胶是一类新型智能材料，最近作为生物材料引起了人们的关注。在本研究中，已开发出温度敏感水凝胶的磁性纳米复合材料，并证明其对交变磁场有响应。通过将超顺磁性Fe(3)O(4)颗粒掺入负温度敏感聚(N-异丙基丙烯酰胺)水凝胶中来合成纳米复合材料。对该系统进行了温度响应性溶胀、施加交变磁场时的远程加热以及远程控制药物递送应用等方面的表征。外部交变磁场中的温度升高取决于系统中Fe(3)O(4)颗粒的负载量。对远程控制药物释放的初步研究表明，在交变磁场存在的情况下释放减少。
