Pietrzak Robert H, Snyder Peter J, Jackson Colleen E, Olver James, Norman Trevor, Piskulic Danijela, Maruff Paul
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Hum Psychopharmacol. 2009 Mar;24(2):113-21. doi: 10.1002/hup.998.
This study examined between- and within-subject stability of cognitive performance in individuals with chronic schizophrenia.
Thirty individuals with schizophrenia and 20 healthy controls matched by age, sex, education, and estimated IQ underwent repeated cognitive assessments at baseline and 30 days using computerized tests of psychomotor function, visual attention/information processing, non-verbal learning, and executive function.
Compared to healthy controls, individuals with schizophrenia scored lower on all cognitive measures and demonstrated greater variability in cognitive performance. Within-subject variability in cognitive performance in both the schizophrenia and healthy control groups remained stable at brief (i.e., hours) and intermediate (i.e., one month) assessments.
These results demonstrate the stability of between- and within-subject variability in cognitive performance in schizophrenia, and suggest that variability in cognitive performance may reflect an inherent characteristic of the disorder, rather than differences in test-retest reliability/error of cognitive measures.
本研究考察了慢性精神分裂症患者认知表现的组间和组内稳定性。
30名精神分裂症患者和20名在年龄、性别、教育程度及估计智商方面相匹配的健康对照者，在基线和30天时使用心理运动功能、视觉注意力/信息处理、非言语学习和执行功能的计算机化测试进行重复认知评估。
与健康对照者相比，精神分裂症患者在所有认知测量上得分更低，且认知表现的变异性更大。精神分裂症组和健康对照组在认知表现上的组内变异性在短期（即数小时）和中期（即一个月）评估中均保持稳定。
这些结果证明了精神分裂症患者认知表现的组间和组内变异性的稳定性，并表明认知表现的变异性可能反映了该疾病的固有特征，而非认知测量的重测信度/误差差异。
