什么是毒力因子？
What is a virulence factor?
作者信息
Cross Alan S
机构信息
Center for Vaccine Development, University of Maryland School of Medicine, 685 W, Baltimore Street, HSF 1 480, Baltimore, MD 21201, USA.
出版信息
Crit Care. 2008;12(6):196. doi: 10.1186/cc7127. Epub 2008 Dec 2.
Abstract
Bacterial virulence factors enable a host to replicate and disseminate within a host in part by subverting or eluding host defenses. The use of genomic techniques has led to the identification of new virulence factors that may serve as targets for new therapies. These putative virulence factors must be rigorously evaluated with in vitro and in vivo studies with an awareness of the technical limitations of each approach as well as an assessment of the prevalence of this factor in clinical bacterial isolates retrieved from appropriately controlled epidemiologic studies.
摘要
细菌毒力因子能够通过破坏或逃避宿主防御机制，使病原体在宿主体内复制和传播。基因组技术的应用已促使人们鉴定出可能成为新疗法靶点的新毒力因子。这些假定的毒力因子必须通过体外和体内研究进行严格评估，同时要意识到每种方法的技术局限性，并评估从适当对照的流行病学研究中获得的临床细菌分离株中该因子的流行情况。
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本文引用的文献
1
Bench-to-bedside review: Bacterial virulence and subversion of host defences.从 bench 到床边的综述：细菌毒力与宿主防御的颠覆
Crit Care. 2008;12(6):234. doi: 10.1186/cc7091. Epub 2008 Nov 10.
2
Choice of bacteria in animal models of sepsis.脓毒症动物模型中细菌的选择
Infect Immun. 1993 Jul;61(7):2741-7. doi: 10.1128/iai.61.7.2741-2747.1993.
3
The importance of a lipopolysaccharide-initiated, cytokine-mediated host defense mechanism in mice against extraintestinally invasive Escherichia coli.脂多糖引发、细胞因子介导的宿主防御机制在小鼠抵抗肠外侵袭性大肠杆菌中的重要性。
J Clin Invest. 1995 Aug;96(2):676-86. doi: 10.1172/JCI118110.
4
Molecular cloning of the K1 capsular polysaccharide genes of E. coli.大肠杆菌K1荚膜多糖基因的分子克隆
Nature. 1981 Feb 19;289(5799):696-8. doi: 10.1038/289696b0.
5
The importance of the K1 capsule in invasive infections caused by Escherichia coli.K1 荚膜在大肠杆菌引起的侵袭性感染中的重要性。
J Infect Dis. 1984 Feb;149(2):184-93. doi: 10.1093/infdis/149.2.184.
6
Mouse virulence of K(L) antigen-containing strains of Escherichia coli.含K（L）抗原的大肠杆菌菌株对小鼠的毒力
J Bacteriol. 1969 Nov;100(2):730-7. doi: 10.1128/jb.100.2.730-737.1969.
7
8
Plasma endotoxin concentration in healthy primates and during E. coli-induced shock.健康灵长类动物及大肠杆菌诱导性休克期间的血浆内毒素浓度。
Crit Care Med. 1988 Jun;16(6):601-5. doi: 10.1097/00003246-198806000-00007.
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