Espinosa Gerard, Cervera Ricard
Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia, Hospital Clínic, Barcelona, Catalonia, Spain.
Arthritis Res Ther. 2008;10(6):230. doi: 10.1186/ar2536. Epub 2008 Dec 15.
Antiphospholipid syndrome is diagnosed when arterial or venous thrombosis or recurrent miscarriages occur in a person in whom laboratory tests for antiphospholipid antibodies (anticardiolipin antibodies and/or lupus anticoagulant and/or anti-beta 2-glycoprotein I) are positive. Despite the strong association between antiphospho-lipid antibodies and thrombosis, their pathogenic role in the development of thrombosis has not been fully elucidated. Novel mechanisms involving both the complement pathway and micro-particles have been described. The knowledge of these new pathogenic approaches might identify novel therapeutic targets and therefore may improve the management of these patients.
抗磷脂抗体（抗心磷脂抗体和/或狼疮抗凝物和/或抗β2糖蛋白I）实验室检测呈阳性的患者发生动脉或静脉血栓形成或反复流产。尽管抗磷脂抗体与血栓形成之间存在密切关联，但其在血栓形成过程中的致病作用尚未完全阐明。已描述了涉及补体途径和微粒的新机制。了解这些新的致病途径可能会确定新的治疗靶点，从而改善这些患者的治疗管理。
