Vicenová B, Vopálenský V, Burýšek L, Pospíšek M
Department of Genetics and Microbiology, Faculty of Science, Charles University, Prague, Czech Republic.
Physiol Res. 2009;58(4):481-498. doi: 10.33549/physiolres.931673. Epub 2008 Dec 17.
There is an increasing evidence linking dysbalance between various proinflammatory mediators and higher risk of cardiovascular events and pathologies. Likewise, some of the cardiovascular diseases lately appeared to have an autoimmune component. Interleukin-1 (IL-1), a master regulator of diverse inflammatory processes in higher eukaryotes and the key player in numerous autoimmune disorders including rheumatoid arthritis, diabetes mellitus or systemic sclerosis, has recently been proved to be involved in development of several cardiovascular diseases as well. This report aims to give a summary on current knowledge about the IL-1 signaling pathways and about the implication of IL-1 and the IL-1 receptor antagonist (IL-1Ra) in some of the diseases of the cardiovascular system.
越来越多的证据表明，各种促炎介质之间的失衡与心血管事件和病变的高风险相关。同样，一些心血管疾病最近似乎具有自身免疫成分。白细胞介素-1（IL-1）是高等真核生物中多种炎症过程的主要调节因子，也是包括类风湿性关节炎、糖尿病或系统性硬化症在内的多种自身免疫性疾病的关键参与者，最近也被证明与几种心血管疾病的发展有关。本报告旨在总结关于IL-1信号通路以及IL-1和IL-1受体拮抗剂（IL-1Ra）在某些心血管系统疾病中的作用的现有知识。
