Sun X, Zhang H, Gao C, Zhang G, Xu L, Lv M, Chai W
Department of Anaesthesiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
J Int Med Res. 2008 Nov-Dec;36(6):1305-10. doi: 10.1177/147323000803600618.
The effects of propofol on glucose metabolism in different cerebral regions were observed, using positron emission tomography (PET) technology, to determine a possible cerebral target region. Seven healthy volunteers were injected with (18)F-fluorodeoxyglucose developing agent for PET scanning whilst awake (control group T1), during sedation (induced by 1.5 microg/ml propofol administered by target controlled injection [TCI], group T2) and when unconsciousness (induced by 2.5 microg/ml propofol administered by TCI, group T3). Whole brain glucose metabolism was reduced during propofol anaesthesia; this was initially observed in the cortical areas at the lower dose of propofol (group T2) but extended to the subcortical regions, especially the thalamus and hippocampus, at the higher dose (group T3). This suggests that these regions of the brain might be important targets that are susceptible to propofol.
利用正电子发射断层扫描（PET）技术观察丙泊酚对不同脑区葡萄糖代谢的影响，以确定可能的脑靶向区域。七名健康志愿者在清醒状态下（对照组T1）、镇静状态下（由靶控输注[TCI]给予1.5微克/毫升丙泊酚诱导，T2组）和无意识状态下（由TCI给予2.5微克/毫升丙泊酚诱导，T3组）注射用于PET扫描的（18）F-氟脱氧葡萄糖显影剂。丙泊酚麻醉期间全脑葡萄糖代谢降低；最初在较低剂量丙泊酚时（T2组）在皮质区域观察到这种情况，但在较高剂量时（T3组）扩展到皮质下区域，尤其是丘脑和海马体。这表明大脑的这些区域可能是对丙泊酚敏感的重要靶点。
