Magalhães Lizandra G, Machado Carla Botelho, Morais Enyara Rezende, Moreira Erika Bueno de Carvalho, Soares Cláudia Sossai, da Silva Sérgio Henrique, Da Silva Filho Ademar A, Rodrigues Vanderlei
Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900, Ribeirão Preto, São Paulo, Brazil.
Parasitol Res. 2009 Apr;104(5):1197-201. doi: 10.1007/s00436-008-1311-y. Epub 2008 Dec 19.
The in vitro schistosomicidal activity of curcumin (doses ranging from 5 to 100 microM) was carried out against Schistosoma mansoni adult worms. Curcumin (at 50 and 100 microM) caused death of all worms. When tested at the doses of 5 and 20 microM, it decreased the worm viability in comparison with negative (Roswell Memorial Park Institute (RPMI) 1640 medium alone or RPMI 1640 medium with 10% dimethyl sulfoxide) and positive (heat-killed worms at 56 degrees C or praziquantel 10 microM) control groups. All pairs of coupled adult worms were separated into individual male and female by the action of curcumin at the doses of 20 to 100 microM. When tested at 5 and 10 microM, curcumin reduced egg production by 50% in comparison with the positive control group. It is the first time that the schistosomicidal activity has been reported for curcumin.
对姜黄素（剂量范围为5至100微摩尔）针对曼氏血吸虫成虫进行了体外杀血吸虫活性研究。姜黄素（50和100微摩尔）致使所有蠕虫死亡。当以5和20微摩尔的剂量进行测试时，与阴性对照组（单独的罗斯韦尔帕克纪念研究所（RPMI）1640培养基或含10%二甲基亚砜的RPMI 1640培养基）和阳性对照组（56℃热灭活蠕虫或10微摩尔吡喹酮）相比，其降低了蠕虫的活力。在20至100微摩尔剂量的姜黄素作用下，所有配对的成虫均被分离为单独的雄虫和雌虫。当以5和10微摩尔进行测试时，与阳性对照组相比，姜黄素使产卵量减少了50%。这是首次报道姜黄素具有杀血吸虫活性。
