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Vitamin supplement use and risk for breast cancer: the Shanghai Breast Cancer Study.维生素补充剂的使用与乳腺癌风险：上海乳腺癌研究
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Hawaii cohort study of serum micronutrient concentrations and clearance of incident oncogenic human papillomavirus infection of the cervix.夏威夷血清微量营养素浓度与宫颈致癌性人乳头瘤病毒感染清除情况的队列研究。
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Plasma responses in human subjects after ingestions of multiple doses of natural alpha-cryptoxanthin: a pilot study.多剂量摄入天然α-隐黄质后人体受试者的血浆反应：一项初步研究。
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Beta-cryptoxanthin suppresses the growth of immortalized human bronchial epithelial cells and non-small-cell lung cancer cells and up-regulates retinoic acid receptor beta expression.β-隐黄质抑制永生化人支气管上皮细胞和非小细胞肺癌细胞的生长，并上调视黄酸受体β的表达。
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Plasma carotenoids, retinol, and tocopherols and risk of breast cancer.血浆类胡萝卜素、视黄醇、生育酚与乳腺癌风险
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血浆类胡萝卜素、生育酚、视黄醇与乳腺癌风险：上海女性健康研究（SWHS）的结果

Plasma carotenoids, tocopherols, retinol and breast cancer risk: results from the Shanghai Women Health Study (SWHS).

作者信息

Dorjgochoo Tsogzolmaa, Gao Yu-Tang, Chow Wong-Ho, Shu Xiao-Ou, Li Honglan, Yang Gong, Cai Qiuyin, Rothman Nathaniel, Cai Hui, Franke Adrian A, Zheng Wei, Dai Qi

机构信息

Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.

出版信息

Breast Cancer Res Treat. 2009 Sep;117(2):381-9. doi: 10.1007/s10549-008-0270-4. Epub 2008 Dec 20.

DOI:10.1007/s10549-008-0270-4
PMID:19096929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2728141/
Abstract

Evidence from some previous studies suggests that lipophilic antioxidants, particularly carotenoids, may reduce the risk of breast cancer. We prospectively investigated the associations of plasma levels of tocopherols, retinol, carotenoids with the risk of developing breast cancer among Chinese women. We conducted a study of 365 incident breast cancer cases and 726 individually matched controls nested within a large cohort study of women aged 40-70 years at baseline. We observed no associations between breast cancer risk and any of the tocopherols, retinol, and most carotenoids. However, high levels of plasma lycopene other than trans, 5- and 7-cis or trans alpha-cryptoxanthin were inversely associated with the risk of developing breast cancer. Our results do not support an overall protective effect of lipophilic antioxidants on breast cancer risk. The few inverse associations observed for subtype of carotenoids may need to be confirmed in future studies.

摘要

一些先前研究的证据表明，亲脂性抗氧化剂，尤其是类胡萝卜素，可能会降低患乳腺癌的风险。我们前瞻性地研究了中国女性血浆中生育酚、视黄醇、类胡萝卜素水平与患乳腺癌风险之间的关联。我们在一项针对40 - 70岁女性的大型队列研究中，对365例新发乳腺癌病例和726例个体匹配对照进行了研究，这些女性在基线时年龄在40至70岁之间。我们未观察到乳腺癌风险与任何生育酚、视黄醇及大多数类胡萝卜素之间存在关联。然而，除反式、5 - 顺式和7 - 顺式或反式α - 隐黄质之外的血浆番茄红素水平较高与患乳腺癌的风险呈负相关。我们的结果不支持亲脂性抗氧化剂对乳腺癌风险具有总体保护作用这一观点。观察到的类胡萝卜素亚型的少数负相关关联可能需要在未来的研究中得到证实。