Bassingthwaighte James, Hunter Peter, Noble Denis
Department of Physiology, Anatomy & Genetics, Oxford, UK.
Exp Physiol. 2009 May;94(5):597-605. doi: 10.1113/expphysiol.2008.044099. Epub 2008 Dec 19.
The Physiome Project, exemplified by the Cardiac Physiome, is now 10 years old. In this article, we review past progress and future challenges in developing a quantitative framework for understanding human physiology that incorporates both genetic inheritance and environmental influence. Despite the enormity of the challenge, which is certainly greater than that facing the pioneers of the human genome project 20 years ago, there is reason for optimism that real and accelerating progress is being made.
以心脏生理组学为代表的生理组学项目如今已有10年历史。在本文中，我们回顾了在建立一个整合遗传继承和环境影响以理解人类生理学的定量框架方面过去取得的进展和未来面临的挑战。尽管这项挑战艰巨无比，肯定比20年前人类基因组计划的先驱们所面临的挑战更大，但仍有理由感到乐观，因为正在取得切实且加速的进展。
