Jyoti Amar, Sethi Pallavi, Sharma Deepak
Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Epilepsy Behav. 2009 Feb;14(2):300-8. doi: 10.1016/j.yebeh.2008.11.011. Epub 2008 Dec 17.
The purpose of the study was to investigate whether dietary intake of curcumin can inhibit the onset and progression of seizures and their associated pathophysiology in experimental FeCl(3)-induced epileptogenesis. Curcumin was considered for this study because it can cross the blood-brain barrier and bind redox-active metal ions. It is also well known for its antioxidative, anticancer, and anti-inflammatory properties. In the present study, seizures were induced by intracortical injection of FeCl(3) into young rats. Synchronized video/EEG recordings were obtained to diagnose the progression of seizures. Short-term treatment with a curcumin-supplemented diet (1500 pp mw/w) significantly inhibited the onset of grade III and IV seizures in rats with iron-induced epilepsy. The lower dose of curcumin (500 ppm) was not effective in inhibiting grade III seizures, but retarded the onset and progression of generalized seizures. The seizure-suppressing potential of curcumin is explained by the observed biochemical, behavioral, and ultrastructural results. Our results indicate that curcumin significantly prevents generalization of electroclinical seizure activity as well as the pathogenesis associated with iron-induced epileptogenesis.
本研究的目的是调查膳食中摄入姜黄素是否能抑制实验性氯化铁诱导癫痫发生过程中癫痫发作的起始和进展及其相关病理生理学。本研究选用姜黄素是因为它能够穿过血脑屏障并结合具有氧化还原活性的金属离子。它还因其抗氧化、抗癌和抗炎特性而广为人知。在本研究中，通过向幼鼠脑皮质内注射氯化铁诱导癫痫发作。通过同步视频/脑电图记录来诊断癫痫发作的进展。用补充姜黄素的饮食（1500 ppm 质量比/体重）进行短期治疗可显著抑制铁诱导癫痫大鼠III级和IV级癫痫发作的起始。较低剂量的姜黄素（500 ppm）在抑制III级癫痫发作方面无效，但可延缓全身性癫痫发作的起始和进展。观察到的生化、行为和超微结构结果解释了姜黄素的癫痫抑制潜力。我们的结果表明，姜黄素可显著预防电临床癫痫活动的泛化以及与铁诱导癫痫发生相关的发病机制。
