Tanaka Masaaki, Mizuno Kei, Tajima Seiki, Sasabe Tetsuya, Watanabe Yasuyoshi
Department of Physiology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka City, Osaka 545-8585, Japan.
Life Sci. 2009 Feb 13;84(7-8):235-9. doi: 10.1016/j.lfs.2008.12.004. Epub 2008 Dec 7.
Fatigue is a common symptom in modern society. In order to clarify the mechanisms underlying fatigue, we examined the association between central nervous system fatigue and autonomic nerve activity.
The study group consisted of 20 healthy subjects. They performed the 2-back test for 30 min to induce fatigue. Just before and after the fatigue-inducing session, they completed the advanced trail making test (ATMT) for 30 min as a fatigue-evaluating task session. In order to measure autonomic nerve activity, electrocardiograms were monitored continuously throughout the experiment.
After the fatigue-inducing task session, impaired task performance was demonstrated based on the total trial number and error counts of the ATMT. During the task session, although task performance as measured using the accuracy and the mean reaction time of the 2-back test was almost unchanged, electrocardiographic R-R wave interval analyses showed a decreased high-frequency component power and an increasing trend in the low-frequency component power/high-frequency component power ratio.
Decreased vagal nerve activity and increased sympathetic nerve activity are associated with central nervous system fatigue.
疲劳是现代社会中的常见症状。为了阐明疲劳背后的机制，我们研究了中枢神经系统疲劳与自主神经活动之间的关联。
研究组由20名健康受试者组成。他们进行30分钟的2-back测试以诱导疲劳。在疲劳诱导期之前和之后，他们完成30分钟的高级连线测试（ATMT）作为疲劳评估任务期。为了测量自主神经活动，在整个实验过程中持续监测心电图。
在疲劳诱导任务期后，基于ATMT的总试验次数和错误计数显示任务表现受损。在任务期内，尽管使用2-back测试的准确性和平均反应时间测量的任务表现几乎没有变化，但心电图R-R波间期分析显示高频成分功率降低，低频成分功率/高频成分功率比值有增加趋势。
迷走神经活动降低和交感神经活动增加与中枢神经系统疲劳有关。
