van Gaalen Kim W, Jansonius Nomdo M, Koopmans Steven A, Terwee Thom, Kooijman Aart C
Laboratory of Experimental Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
J Cataract Refract Surg. 2009 Jan;35(1):47-56. doi: 10.1016/j.jcrs.2008.09.016.
To find a contrast sensitivity test that can be used clinically to evaluate interventions aimed at minimizing spherical aberration and determine the circumstances under which these tests should be performed.
Laboratory of Experimental Ophthalmology, University of Groningen, Groningen, The Netherlands.
Contrast sensitivity tests were performed using 2 experimental designs. Design 1 was with a natural pupil under mesopic and photopic conditions. Design 2 was with a 5.0 mm artificial pupil after cycloplegia under photopic conditions only. Two computerized tests (vertical sine-modulated gratings [VSG] and Holladay circular sine-modulated patterns [HACSS]) and 5 chart tests (Pelli-Robson, acuity-measuring letter charts at low contrast [2.5% and 10%], VectorVision, and edge contrast sensitivity) were used. Spherical aberration was assessed with a Hartmann-Shack wavefront analyzer.
Forty-nine healthy subjects aged 20 to 35 years (n = 24) and 55 to 70 years (n = 25) participated. Design 2 showed a significant relationship between contrast sensitivity and spherical aberration with the HACSS at 3 cycles per degree (cpd) (P = .03) and 6 cpd (P = .01) and with the VSG at 6 cpd (P = .01). Design 1 yielded no significant relationships.
Using an artificial pupil, a relationship between contrast sensitivity and spherical aberration was established with the VSG and HACSS tests but not with the chart tests. No test showed a relationship using natural pupils under either lighting condition. Chart tests are unsuitable for uncovering contrast sensitivity differences related to differences in spherical aberration, as typically found in healthy phakic eyes.
寻找一种可在临床上用于评估旨在最小化球差的干预措施的对比敏感度测试，并确定进行这些测试的情况。
荷兰格罗宁根大学实验眼科学实验室。
使用两种实验设计进行对比敏感度测试。设计1是在中度照明和明视条件下使用自然瞳孔。设计2是在睫状肌麻痹后仅在明视条件下使用5.0毫米人工瞳孔。使用了两种计算机化测试（垂直正弦调制光栅[VSG]和霍拉迪圆形正弦调制图案[HACSS]）和五种图表测试（佩利-罗布森测试、低对比度[2.5%和10%]的视力测量字母图表、VectorVision测试和边缘对比敏感度测试）。使用哈特曼-夏克波前分析仪评估球差。
49名年龄在20至35岁（n = 24）和55至70岁（n = 25）的健康受试者参与了研究。设计2显示，在每度3周/度（cpd）（P = 0.03）和6 cpd（P = 0.01）时，HACSS测试的对比敏感度与球差之间存在显著关系，在6 cpd时VSG测试的对比敏感度与球差之间也存在显著关系（P = 0.01）。设计1未得出显著关系。
使用人工瞳孔时，VSG和HACSS测试建立了对比敏感度与球差之间的关系，但图表测试未建立这种关系。在任何一种光照条件下，使用自然瞳孔时，没有测试显示出这种关系。图表测试不适用于发现与健康有晶状体眼中典型的球差差异相关的对比敏感度差异。
