Jia Wuli, Zhou Jiawei, Lu Zhong-Lin, Lesmes Luis A, Huang Chang-Bing
Key Laboratory of Behavioral Science, Institute of Psychology, CAS, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
Key Laboratory of Behavioral Science, Institute of Psychology, CAS, Beijing, China.
Vision Res. 2015 Sep;114:135-41. doi: 10.1016/j.visres.2015.02.003. Epub 2015 Feb 19.
Amblyopia screening during childhood is critical for early detection and successful treatment. In the current study, we develop and evaluate a screening method that exploits the imbalanced interocular inhibition between amblyopic and fellow eyes. In nineteen subjects with anisometropic amblyopia and twenty-two age-matched subjects with myopia, we measured the area under the contrast sensitivity functions (AUCSFs) in eight monocular conditions defined by the tested eye (left, right), patching of the untested eye (translucent, opaque), and refractive status (corrected, uncorrected). For each tested eye, we defined the inhibition index as the ratio between the AUCSF values obtained in the translucent and opaque patching conditions of the untested eye. To evaluate the screening potential of the inhibition index, we compared results from patients with amblyopia and myopia. With and without optical correction, the index was significantly lower in the amblyopic eye than in the fellow eye of the amblyopic subjects and both eyes of the myopic subjects. No significant difference was found among the two eyes of the myopic subjects and the fellow eyes of the amblyopic subjects. With the inhibition index as the predictor, a logistic regression model successfully discriminated amblyopic eyes from myopic eyes with 100% accuracy in the uncorrected condition. In the corrected condition, with the inhibition index and interocular visual acuity difference as predictors, amblyopic eyes were likewise discriminated from myopic eyes with 100% accuracy. This pattern of CSF changes, caused by the different patching modes of the untested eye, provides a potential CSF signature to discriminate anisometropic amblyopia from myopia.
儿童期弱视筛查对于早期发现和成功治疗至关重要。在本研究中，我们开发并评估了一种利用弱视眼和对侧眼之间不平衡的眼间抑制作用的筛查方法。在19名屈光参差性弱视患者和22名年龄匹配的近视患者中，我们测量了在由被测试眼（左眼、右眼）、未被测试眼的遮盖方式（半透明、不透明）和屈光状态（矫正、未矫正）所定义的8种单眼条件下的对比敏感度函数曲线下面积（AUCSFs）。对于每只被测试眼，我们将抑制指数定义为在未被测试眼的半透明和不透明遮盖条件下获得的AUCSF值之比。为了评估抑制指数的筛查潜力，我们比较了弱视患者和近视患者的结果。无论有无光学矫正，弱视眼的该指数均显著低于弱视患者的对侧眼以及近视患者的双眼。近视患者的双眼之间以及弱视患者的对侧眼之间未发现显著差异。以抑制指数作为预测指标，逻辑回归模型在未矫正条件下以100%的准确率成功区分了弱视眼和近视眼中的弱视眼。在矫正条件下，以抑制指数和双眼视力差异作为预测指标，同样以100%的准确率区分了弱视眼和近视眼中的弱视眼。未被测试眼的不同遮盖方式所导致的这种CSF变化模式，提供了一种潜在的CSF特征，可用于区分屈光参差性弱视和近视。
