a Department of Otorhinolaryngology and Head and Neck Surgery , Diskapi Yildirim Beyazit Research and Training Hospital , Ankara , Turkey.
b Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Medicine , Ankara Yildirim Beyazit University, Bilkent Campus , Ankara , Turkey.
J Enzyme Inhib Med Chem. 2019 Dec;34(1):459-464. doi: 10.1080/14756366.2018.1555157.
Head and neck cancer (HNC) is one of the most common malignancies in the world. HNC is a group of cancers that starts in the mouth, nose, throat, larynx, sinuses, or salivary glands. According to this section of the body parts; induction of cancer can be associated with CO and oxidative stress. The aim of this study is to assess the activities of carbonic anhydrase (CA), catalase (CAT), paraoxonase1 (PON1), and xanthine oxidase (XO) activities in 89 HNC patients and 115 healthy volunteers. Paraoxonase1 activity was found lower in HNC cancer patients. There is no statistically significant difference between patients and controls for catalase, carbonic anhydrase, and xanthine oxidase enzyme levels. According to this results, paraoxonase1 levels could be a candidate as an oxidative marker in HNC patients, but further studies are needed to investigate the other type of cancer related PON1 and the other enzyme levels.
头颈部癌症（HNC）是世界上最常见的恶性肿瘤之一。HNC 是一组起源于口腔、鼻腔、喉咙、喉、鼻窦或唾液腺的癌症。根据这部分身体部位；癌症的诱导可能与 CO 和氧化应激有关。本研究旨在评估 89 例 HNC 患者和 115 名健康志愿者的碳酸酐酶（CA）、过氧化氢酶（CAT）、对氧磷酶 1（PON1）和黄嘌呤氧化酶（XO）活性。发现 HNC 癌症患者的对氧磷酶 1 活性较低。CAT、碳酸酐酶和黄嘌呤氧化酶酶水平在患者和对照组之间无统计学差异。根据这些结果，对氧磷酶 1 水平可能是 HNC 患者氧化标志物的候选物，但需要进一步研究以调查其他类型的癌症相关 PON1 和其他酶水平。
