Yoon Chan-Seok, Hyung Woo Jin, Lee Ju-Han, Chae Yang-Seok, Won Nam Hee, Yeom Bum-Woo, Choi Jong Sang
Department of Surgery, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Korea.
Hepatogastroenterology. 2008 Sep-Oct;55(86-87):1916-20.
BACKGROUND/AIMS: This investigation aimed to elucidate the expression patterns of S100A4 and adhesion molecules in gastric carcinoma and to estimate their correlation with clinicopathologic parameters.
The expression of S100A4, E-cadherin, alpha- and beta-catenin was studied in 251 gastric carcinoma specimens through immunohistochemical staining.
The positive expression of S100A4 was significantly associated with advanced gastric cancer, higher pTNM stage, and poorer survival rates, especially when present in nuclear staining. The reduced expression of adhesion molecules was significantly associated with diffuse type of gastric cancer. The reduced expression of beta-catenin was significantly associated with lymph node metastasis, especially in early gastric cancer. The coexpression status of S100A4-positive and reduced beta-catenin was significantly associated with larger tumor size, advanced tumor depth, and higher pTNM stage.
S100A4 and adhesion molecule expression may be a useful prognostic marker for individual gastric cancer patients.
背景/目的：本研究旨在阐明S100A4和黏附分子在胃癌中的表达模式，并评估它们与临床病理参数的相关性。
通过免疫组织化学染色研究251例胃癌标本中S100A4、E-钙黏蛋白、α-连环蛋白和β-连环蛋白的表达。
S100A4的阳性表达与进展期胃癌、较高的pTNM分期及较差的生存率显著相关，尤其是细胞核染色阳性时。黏附分子表达降低与弥漫型胃癌显著相关。β-连环蛋白表达降低与淋巴结转移显著相关，尤其是早期胃癌。S100A4阳性与β-连环蛋白表达降低的共表达状态与肿瘤体积较大、肿瘤浸润深度较深及pTNM分期较高显著相关。
S100A4和黏附分子表达可能是个体胃癌患者有用的预后标志物。
