Department of Gastroenterology, the First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China.
Chin J Cancer Res. 2012 Mar;24(1):23-8. doi: 10.1007/s11670-012-0023-0.
To investigate the expressions of caveolin-1, E-cadherin and β-catenin in gastric carcinoma, precancerous gastric and chronic non-atrophic gastritis tissues, and evaluate the correlation of these expressions with the development of gastric cancer.
The expressions of caveolin-1, E-cadherin and β-catenin were detected by biotin-streptavidin- peroxidase (SP) immunohistochemistry on 58 gastric cancer tissues, 40 precancerous gastric tissues and 42 chronic non-atrophic gastritis tissues. The correlation between the expressions of caveolin-1, E-cadherin and β-catenin, and the clinicopathologic parameters of gastric cancer was analyzed retrospectively.
The positive rates of caveolin-1 and E-cadherin expressions in gastric carcinoma were significantly lower than precancerous gastric and chronic non-atrophic gastritis tissues (P<0.01). An abnormal rate of β-catenin expression in gastric carcinoma was higher than precancerous gastric and chronic non-atrophic gastritis tissues (P<0.01). Moreover, low expressions of caveolin-1, E-cadherin and β-catenin correlated with tumor size, depth of invasion, lymph node metastasis and TNM stage (P<0.05). The positive rates of caveolin-1 and E-cadherin expressions decreased (P<0.01), while an abnormal rate of β-catenin expression increased inversely, with the degree of atypical hyperplasia (P<0.01). Caveolin-1 expression correlated positively with E-cadherin (r=0.41, P<0.05). Caveolin-1 (r=-0.36, P<0.05) and E-cadherin (r=-0.45, P<0.05) expressions negatively correlated with abnormal β-catenin expression.
These results suggested that dysregulated expressions of caveolin-1, E-cadherin and β-catenin correlated with the development of gastric cancer and its biological behavior.
探讨小窝蛋白-1（caveolin-1）、E-钙黏附蛋白（E-cadherin）和β-连环蛋白（β-catenin）在胃癌、癌前胃组织和慢性非萎缩性胃炎组织中的表达，并评估其与胃癌发生发展的相关性。
采用免疫组织化学链霉亲和素-过氧化物酶（SP）法检测 58 例胃癌组织、40 例癌前胃组织和 42 例慢性非萎缩性胃炎组织中 caveolin-1、E-cadherin 和β-catenin 的表达，并回顾性分析 caveolin-1、E-cadherin 和β-catenin 的表达与胃癌临床病理参数的关系。
胃癌组织中 caveolin-1 和 E-cadherin 的阳性表达率明显低于癌前胃组织和慢性非萎缩性胃炎组织（P<0.01），β-catenin 异常表达率明显高于癌前胃组织和慢性非萎缩性胃炎组织（P<0.01）。此外，caveolin-1、E-cadherin 和β-catenin 的低表达与肿瘤大小、浸润深度、淋巴结转移和 TNM 分期有关（P<0.05）。caveolin-1 和 E-cadherin 的阳性表达率降低（P<0.01），β-catenin 异常表达率升高（P<0.01），随着不典型增生程度的增加而增加。caveolin-1 表达与 E-cadherin 呈正相关（r=0.41，P<0.05），caveolin-1（r=-0.36，P<0.05）和 E-cadherin（r=-0.45，P<0.05）表达与异常β-catenin 表达呈负相关。
caveolin-1、E-cadherin 和β-catenin 的表达失调与胃癌的发生发展及其生物学行为有关。
