Reibman Joan, Marmor Michael, Filner Joshua, Fernandez-Beros Maria-Elena, Rogers Linda, Perez-Perez Guillermo I, Blaser Martin J
Department of Medicine, New York University School of Medicine, New York City, New York, USA.
PLoS One. 2008;3(12):e4060. doi: 10.1371/journal.pone.0004060. Epub 2008 Dec 29.
Microbial exposures have been suggested to confer protection from allergic disorders and reduced exposures to gastrointestinal microbiota have been proposed as an explanation for the increase in asthma prevalence. Since the general prevalence of Helicobacter pylori has been decreasing, we hypothesized that H. pylori serostatus would be inversely related to the presence of asthma.
Adults were recruited to participate in the New York University (NYU)/Bellevue Asthma Registry in New York City. Adult asthma cases (N = 318) and controls (N = 208) were identified and serum IgG antibodies to H. pylori whole cell antigens or the immunodominant CagA antigen were measured.
As expected, the asthma cases and controls differed with respect to atopy and lung function. Seropositivity to H. pylori or CagA antigen was present in 47.1% of the total case and control study population. Asthma was inversely associated with CagA seropositivity (OR = 0.57, 95% CI = 0.36-0.89). Median age of onset of asthma (doctor's diagnosis) was older (21 years) among individuals with CagA+ strains than among H. pylori- individuals (11 years) (p = 0.006).
These data are consistent with the hypothesis that colonization with CagA+ H. pylori strains is inversely associated with asthma and is associated with an older age of asthma onset in an urban population. The data suggest H. pylori as a marker for protection.
有研究表明，微生物暴露可能对过敏性疾病起到保护作用，而胃肠道微生物群暴露减少被认为是哮喘患病率上升的一个原因。由于幽门螺杆菌的总体患病率一直在下降，我们推测幽门螺杆菌血清状态与哮喘的存在呈负相关。
招募成年人参与纽约市纽约大学/贝莱维哮喘登记研究。确定成年哮喘病例（N = 318）和对照（N = 208），并检测血清中针对幽门螺杆菌全细胞抗原或免疫显性CagA抗原的IgG抗体。
正如预期的那样，哮喘病例和对照在特应性和肺功能方面存在差异。在全部病例和对照研究人群中，47.1%的人对幽门螺杆菌或CagA抗原呈血清阳性。哮喘与CagA血清阳性呈负相关（比值比 = 0.57，95%置信区间 = 0.36 - 0.89）。感染CagA + 菌株的个体中哮喘（医生诊断）的发病年龄中位数（21岁）比幽门螺杆菌阴性个体（11岁）更大（p = 0.006）。
这些数据与以下假设一致，即CagA + 幽门螺杆菌菌株的定植与哮喘呈负相关，并且在城市人群中与哮喘发病年龄较大有关。数据表明幽门螺杆菌是一种保护标志物。
