Sublette M Elizabeth, Milak Matthew S, Hibbeln Joseph R, Freed Peter J, Oquendo Maria A, Malone Kevin M, Parsey Ramin V, Mann J John
Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, Unit 42, New York, NY 10032, USA.
Prostaglandins Leukot Essent Fatty Acids. 2009 Jan;80(1):57-64. doi: 10.1016/j.plefa.2008.11.004. Epub 2009 Jan 6.
Deficiencies in polyunsaturated essential fatty acids (PUFA) are implicated in mood disorders, although mechanisms of action and regional specificity in the brain are unknown. We hypothesized that plasma phospholipid PUFA levels are correlated with regionally specific relative cerebral metabolic rates of glucose (rCMRglu). Medication-free depressed subjects (N=29) were studied using [(18)F]-fluoro-2-deoxyglucose positron emission tomography. Docosahexaenoic acid (22:6n-3), arachidonic acid (20:4n-6), and eicosapentaenoic acid (20:5n-3) were assessed as a percentage of total phospholipid PUFA (DHA%, AA%, and EPA%, respectively). DHA% and AA% correlated positively with rCMRglu in temporoparietal cortex. In addition, DHA% correlated negatively with rCMRglu in prefrontal cortex and anterior cingulate. No correlations were seen with EPA%. Thus, under conditions of low plasma DHA, rCMRglu was higher in temporoparietal cortex and lower in anterior cingulate/prefrontal cortex. Opposing effects of DHA on these regions is a hypothesis that could be addressed in future prospective studies with n-3 supplementation. This pilot study is the first to demonstrate fatty acid and regionally specific correlations in the brain between plasma PUFA and rCMRglu in humans.
多不饱和必需脂肪酸（PUFA）缺乏与情绪障碍有关，尽管其作用机制和在大脑中的区域特异性尚不清楚。我们假设血浆磷脂PUFA水平与区域特异性相对脑葡萄糖代谢率（rCMRglu）相关。使用[（18）F] - 氟 - 2 - 脱氧葡萄糖正电子发射断层扫描对未服用药物的抑郁症患者（N = 29）进行研究。评估二十二碳六烯酸（22:6n - 3）、花生四烯酸（20:4n - 6）和二十碳五烯酸（20:5n - 3）占总磷脂PUFA的百分比（分别为DHA%、AA%和EPA%）。DHA%和AA%与颞顶叶皮质的rCMRglu呈正相关。此外，DHA%与前额叶皮质和前扣带回的rCMRglu呈负相关。未发现与EPA%有相关性。因此，在血浆DHA水平较低的情况下，颞顶叶皮质的rCMRglu较高，而前扣带回/前额叶皮质的rCMRglu较低。DHA对这些区域的相反作用是一个假说，可在未来补充n - 3的前瞻性研究中进行探讨。这项初步研究首次证明了人体血浆PUFA与rCMRglu之间在大脑中的脂肪酸和区域特异性相关性。
