Akhlaghi Masoumeh, Bandy Brian
College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada S7N 5C9.
J Mol Cell Cardiol. 2009 Mar;46(3):309-17. doi: 10.1016/j.yjmcc.2008.12.003. Epub 2008 Dec 24.
Flavonoids have long been acknowledged for their unique antioxidant properties, and possess other activities that may be relevant to heart ischemia-reperfusion. They may prevent production of oxidants (e.g. by inhibition of xanthine oxidase and chelation of transition metals), inhibit oxidants from attacking cellular targets (e.g. by electron donation and scavenging activities), block propagation of oxidative reactions (by chain-breaking antioxidant activity), and reinforce cellular antioxidant capacity (through sparing effects on other antioxidants and inducing expression of endogenous antioxidants). Flavonoids also possess anti-inflammatory and anti-platelet aggregation effects through inhibiting relevant enzymes and signaling pathways, resulting ultimately in lower oxidant production and better re-establishment of blood in the ischemic zone. Finally, flavonoids are vasodilatory through a variety of mechanisms, one of which is likely interaction with ion channels. These multifaceted activities of flavonoids raise their utility as possible therapeutic interventions to ameliorate ischemia-reperfusion injury.
黄酮类化合物长期以来因其独特的抗氧化特性而受到认可，并且具有其他可能与心脏缺血再灌注相关的活性。它们可能会阻止氧化剂的产生（例如通过抑制黄嘌呤氧化酶和螯合过渡金属），抑制氧化剂攻击细胞靶点（例如通过电子供体和清除活性），阻断氧化反应的传播（通过链断裂抗氧化活性），并增强细胞抗氧化能力（通过对其他抗氧化剂的节约作用和诱导内源性抗氧化剂的表达）。黄酮类化合物还通过抑制相关酶和信号通路而具有抗炎和抗血小板聚集作用，最终导致氧化剂产生减少以及缺血区血液更好地重新建立。最后，黄酮类化合物通过多种机制发挥血管舒张作用，其中一种可能是与离子通道相互作用。黄酮类化合物的这些多方面活性提高了它们作为改善缺血再灌注损伤的可能治疗干预措施的效用。
