Zadeh Behzad Sharif Makhmal, Moghimi Hamidreza, Santos Paulo, Hadgraft Jonathan, Lane Majella E
School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Int Wound J. 2008 Dec;5(5):633-8. doi: 10.1111/j.1742-481X.2008.00539.x.
Infections of burn wounds are the source of significant problems in burn patients. Early excision of eschar tissue is an ideal solution to avoid sepsis. When early excision is not feasible, the application of topical antimicrobial formulations may be used to control burn wound sepsis. An understanding of the barrier properties of eschar tissue is essential for optimal design of topical antimicrobial formulations. To date, little research has been conducted on the permeability of eschar. Silver sulphadiazine (SSD) is the most frequently used topical agent in burn management. In this study, the permeation of sulphadiazine from aqueous saturated solutions of SSD through human full-thickness burn eschar tissue was studied and compared with permeability through silicone and Carbosil as model membranes. The permeation of sulphadiazine through eschar tissue was significantly higher than that through silicone and Carbosil membranes (P < 0.05). Deconvolution of the data showed that the apparent sulphadiazine diffusion coefficient was much higher in eschar tissue and was comparable to transport through an aqueous protein gel. Further studies on a greater number of compounds are suggested to elucidate the utility of such membranes as predictive models of drug permeability through eschar tissue.
烧伤创面感染是烧伤患者面临的重大问题根源。早期切除焦痂组织是避免败血症的理想解决方案。当早期切除不可行时，可应用局部抗菌制剂来控制烧伤创面败血症。了解焦痂组织的屏障特性对于局部抗菌制剂的优化设计至关重要。迄今为止，关于焦痂渗透性的研究很少。磺胺嘧啶银（SSD）是烧伤治疗中最常用的局部用药。在本研究中，研究了磺胺嘧啶从SSD的饱和水溶液透过人全层烧伤焦痂组织的渗透情况，并与透过硅酮和Carbosil作为模型膜的渗透性进行了比较。磺胺嘧啶透过焦痂组织的渗透率显著高于透过硅酮和Carbosil膜的渗透率（P < 0.05）。数据反卷积显示，焦痂组织中磺胺嘧啶的表观扩散系数高得多，与通过水性蛋白质凝胶的转运相当。建议对更多化合物进行进一步研究，以阐明此类膜作为药物透过焦痂组织渗透性预测模型的效用。
