Abate-Shen Cory, Brown Powel H, Colburn Nancy H, Gerner Eugene W, Green Jeffery E, Lipkin Martin, Nelson William G, Threadgill David
Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Cancer Prev Res (Phila). 2008 Aug;1(3):161-6. doi: 10.1158/1940-6207.CAPR-08-0076.
The past decade has witnessed the unveiling of a powerful new generation of genetically engineered mouse (GEM) models of human cancer, which are proving to be highly effective for elucidating cancer mechanisms and interrogating novel experimental therapeutics. This new generation of GEM models are well suited for chemoprevention research, particularly for investigating progressive stages of carcinogenesis, identifying biomarkers for early detection and intervention, and preclinical assessment of novel agents or combinations of agents. Here we discuss opportunities and challenges for the application of GEM models in prevention research, as well as strategies to maximize their relevance for human cancer.
在过去十年中，新一代强大的人类癌症基因工程小鼠（GEM）模型问世，事实证明这些模型在阐明癌症机制和探究新型实验性疗法方面非常有效。新一代GEM模型非常适合化学预防研究，特别是用于研究致癌作用的进展阶段、识别早期检测和干预的生物标志物，以及对新型药物或药物组合进行临床前评估。在此，我们讨论GEM模型在预防研究中的应用机遇与挑战，以及使其与人类癌症相关性最大化的策略。
