Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK.
Br J Cancer. 2013 Jul 9;109(1):1-7. doi: 10.1038/bjc.2013.280. Epub 2013 Jun 4.
Cancer chemoprevention involves the chronic administration of a synthetic, natural or biological agent to reduce or delay the occurrence of malignancy. The potential value of this approach has been demonstrated with trials in breast, prostate and colon cancer. The paradigm for developing new chemopreventive agents has changed markedly in the last decade and now involves extensive preclinical mechanistic evaluation of agents before clinical trials are instituted and a focus on defining biomarkers of activity that can be used as early predictors of efficacy. This review will summarise the current status of the field of chemoprevention and highlight potential new developments.
癌症化学预防涉及长期给予合成、天然或生物制剂，以减少或延迟恶性肿瘤的发生。这种方法的潜在价值已在乳腺癌、前列腺癌和结肠癌的试验中得到证实。在过去的十年中，开发新的化学预防剂的范例发生了显著变化，现在在进行临床试验之前，需要对药物进行广泛的临床前机制评估，并侧重于定义可作为疗效早期预测指标的活性生物标志物。这篇综述将总结化学预防领域的现状，并强调潜在的新发展。
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