Steiling Katrina, Ryan John, Brody Jerome S, Spira Avrum
The Pulmonary Center, Boston University Medical Center, Boston, Massachusetts 02118, USA.
Cancer Prev Res (Phila). 2008 Nov;1(6):396-403. doi: 10.1158/1940-6207.CAPR-08-0174.
The concept of field cancerization was first introduced over 6 decades ago in the setting of oral cancer. Later, field cancerization involving histologic and molecular changes of neoplasms and adjacent tissue began to be characterized in smokers with or without lung cancer. Investigators also described a diffuse, nonneoplastic field of molecular injury throughout the respiratory tract that is attributable to cigarette smoking and susceptibility to smoking-induced lung disease. The potential molecular origins of field cancerization and the field of injury following cigarette smoke exposure in lung and airway epithelia are critical to understanding their potential impact on clinical diagnostics and therapeutics for smoking-induced lung disease.
“场癌化”概念于60多年前首次在口腔癌背景下被提出。后来，在患有或未患肺癌的吸烟者中，开始对涉及肿瘤及相邻组织的组织学和分子变化的场癌化进行特征描述。研究人员还描述了整个呼吸道存在一个弥漫性的、非肿瘤性的分子损伤区域，这可归因于吸烟以及对吸烟所致肺部疾病的易感性。场癌化的潜在分子起源以及香烟烟雾暴露后肺和气道上皮中的损伤区域，对于理解它们对吸烟所致肺部疾病临床诊断和治疗的潜在影响至关重要。
