Erwin Douglas H, Davidson Eric H
Department of Paleobiology, MRC-121, National Museum of Natural History, PO BOX 37012, Washington, Washington DC 20013-7012, USA.
Nat Rev Genet. 2009 Feb;10(2):141-8. doi: 10.1038/nrg2499. Epub 2009 Jan 13.
Comparative developmental evidence indicates that reorganizations in developmental gene regulatory networks (GRNs) underlie evolutionary changes in animal morphology, including body plans. We argue here that the nature of the evolutionary alterations that arise from regulatory changes depends on the hierarchical position of the change within a GRN. This concept cannot be accomodated by microevolutionary nor macroevolutionary theory. It will soon be possible to investigate these ideas experimentally, by assessing the effects of GRN changes on morphological evolution.
比较发育学证据表明，发育基因调控网络（GRN）的重组是动物形态包括身体结构进化变化的基础。我们在此认为，由调控变化引起的进化改变的性质取决于该变化在GRN中的层级位置。这一概念无法被微进化理论或宏观进化理论所容纳。通过评估GRN变化对形态进化的影响，很快就有可能通过实验来研究这些观点。
