Mancino D, Bevilacqua N
Int Arch Allergy Appl Immunol. 1977;53(2):97-103. doi: 10.1159/000231738.
The adjuvant effect of a subcutaneously injected amorphous silica (Aerosil) to various antigens was studied in guinea pigs. It was demonstrated that silica is able to enhance the humoral immune response to particulate and soluble antigens widely differing in molecular weight and that, in the system employed, adsorption of antigen on silica particles is not absolutely required for its adjuvanticity.
