Hicks R, Skeldon N
Immunology. 1972 Nov;23(5):757-68.
The effectiveness of antigen aerosol-induced desensitization has been investigated in guinea-pigs actively sensitized with antigen, alone or incorporated in Freund's adjuvants. Rates of desensitization, and the ability of animals to regain anaphylactic hypersensitivity following intensive desensitization, have been considered in terms of relative rates of antibody production, levels of circulating antibody, and qualitative differences in the antibody produced. A protective component observed during desensitization in adjuvant-treated animals is considered to be a property both of high levels of circulating antibody and of the presence of certain non-specific factors which interfere with the sensitization process.
在用抗原单独或与弗氏佐剂混合对豚鼠进行主动致敏后，研究了抗原气雾剂诱导脱敏的效果。从抗体产生的相对速率、循环抗体水平以及所产生抗体的质量差异方面，考量了脱敏速率以及动物在强化脱敏后恢复过敏超敏反应的能力。在佐剂处理动物的脱敏过程中观察到的一种保护成分，被认为是高水平循环抗体以及某些干扰致敏过程的非特异性因子共同作用的特性。
