Lucarotti M E, Mountford R A, Bartolo D C
University Department of Surgery, Bristol Royal Infirmary, United Kingdom.
Dis Colon Rectum. 1991 Oct;34(10):865-9. doi: 10.1007/BF02049698.
The management of 14 cases of radiation injury to the intestinal tract over a 4-year period is evaluated. The longest latent interval between radiation treatment and symptoms was 30 years. Eight patients were treated surgically; six were treated conservatively by laser therapy or application of formalin to the affected mucosa. The indications for surgery were rectovaginal fistula (four), rectal stricture (one), radiation proctitis (eight), and small bowel obstruction (one). Seven patients underwent large bowel resection. These consisted of four anastomoses with coloanal J-reservoirs, two low anterior resections, and one coloanal anastomosis without reservoir. There was no perioperative mortality. Morbidity occurred in one of the eight surgical cases. Radical resection of the radiation-damaged rectum has been shown to be a safe and reliable treatment for rectovaginal fistulas, rectal strictures, and proctitis unresponsive to medical measures. Coloanal J-reservoir is the procedure of choice to avoid urgency and frequency symptoms associated with coloanal sleeve anastomosis. Laser therapy for hemorrhagic proctitis can achieve an important place in the management of this problem without recourse to surgery.
对4年间14例肠道放射性损伤的治疗情况进行评估。放疗与症状出现之间最长的潜伏期为30年。8例患者接受了手术治疗;6例采用激光治疗或在受损黏膜处涂抹福尔马林进行保守治疗。手术指征包括直肠阴道瘘(4例)、直肠狭窄(1例)、放射性直肠炎(8例)和小肠梗阻(1例)。7例患者接受了大肠切除术。其中包括4例结肠肛管J形贮袋吻合术、2例低位前切除术和1例无贮袋的结肠肛管吻合术。围手术期无死亡病例。8例手术病例中有1例出现并发症。对于直肠阴道瘘、直肠狭窄以及对药物治疗无效的直肠炎,对受放射性损伤的直肠进行根治性切除已被证明是一种安全可靠的治疗方法。结肠肛管J形贮袋术是避免与结肠肛管套叠吻合相关的便急和便频症状的首选术式。对于出血性直肠炎,激光治疗在不借助手术的情况下可在该问题的治疗中占据重要地位。