Russell J C, Welch J P
Am J Surg. 1979 Apr;137(4):433-42. doi: 10.1016/0002-9610(79)90111-9.
A review of forty cases of radiation-induced gastrointestinal injuries is presented. Based on this experience and reports in the literature, preoperative management and operative technics are discussed. The increased risk of radiation bowel injury is recognized in patients who have had previous operations. Preradiation contrast studies are advised to identify trapped loops of intestine in the pelvis. Small bowel resection is recommended with localized segments of disease. Bypass operations are preferable to avoid any extensive dissections. Bypass operations have anastomotic dehiscence rates similar to those of resections. Proctocolitis is usually managed by diverting colostomy, with resection in a few favorable cases or with treatment failures. Most rectovaginal fistulas are managed by permanent colostomy. Small bowel fistulas are best treated by bypass with partial or total exclusion rather than by primary resection. Vigorous preoperative and postoperative nutritional support and evaluation are vital because of the poor healing qualities of irradiated bowel. Multiple operative procedures should be anticipated because the natural history of radiation bowel injury is slowly progressive.
本文综述了40例放射性胃肠道损伤病例。基于这一经验及文献报道,对术前处理及手术技巧进行了讨论。既往接受过手术的患者发生放射性肠损伤的风险增加。建议在放疗前进行对比检查,以识别盆腔内的肠袢。对于局限性病变,建议行小肠切除术。旁路手术更可取,以避免任何广泛的解剖。旁路手术的吻合口裂开率与切除术相似。直肠结肠炎通常通过结肠造口术进行处理,少数情况良好或治疗失败的病例可行切除术。大多数直肠阴道瘘通过永久性结肠造口术进行处理。小肠瘘最好通过部分或完全排除的旁路手术治疗,而不是一期切除。由于放疗后肠管愈合能力差,术前和术后积极的营养支持及评估至关重要。由于放射性肠损伤的自然病程进展缓慢,应预期进行多次手术。