Overy David, Calati Kathleen, Kahn Jennifer Nielsen, Hsu Ming-Jo, Martín Jesús, Collado Javier, Roemer Terry, Harris Guy, Parish Craig A
Centro de Investigación Básica, Merck, Sharp & Dohme de España, S. A., Josefa Valcárcel, Madrid E-28027, Spain.
Bioorg Med Chem Lett. 2009 Feb 15;19(4):1224-7. doi: 10.1016/j.bmcl.2008.12.081. Epub 2008 Dec 25.
Parnafungins, natural products containing an isoxazolidinone ring, have been isolated from Fusarium larvarum and have been shown to be potent inhibitors of the fungal polyadenosine polymerase. The extraction and analysis of fermentation broths of taxonomically related organisms identified as closely related Fusarium spp. produce not only parnafungin A and B, but also significant quantities of two related components. These members of the paranfungin family of natural products have been isolated and the structure of each has been elucidated. While structurally analogous to parnafungin A, parnafungin C is further elaborated by methylation of a phenolic hydroxyl group, and parnafungin D has both the methyl phenol ether as well as an epoxide in the xanthone ring system. Parnafungin C and D have potent, broad spectrum antifungal activity and also have been shown to target fungal mRNA cleavage and polyadenylation.
帕纳芬净是一类含有异恶唑烷酮环的天然产物，已从幼虫镰刀菌中分离出来，并被证明是真菌多聚腺苷酸聚合酶的有效抑制剂。对分类学上相关的生物体（被鉴定为密切相关的镰刀菌属）发酵液的提取和分析表明，其不仅产生帕纳芬净A和B，还产生大量的两种相关成分。这些天然产物帕纳芬净家族的成员已被分离出来，并且每种的结构都已阐明。虽然帕纳芬净C在结构上与帕纳芬净A类似，但它通过酚羟基的甲基化进一步修饰，而帕纳芬净D在氧杂蒽环系统中既有甲基酚醚又有环氧化物。帕纳芬净C和D具有强大的广谱抗真菌活性，并且也已被证明靶向真菌mRNA的切割和多聚腺苷酸化。
