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[中药多成分药代动力学研究的现状与思考]

[Current situation and consideration of pharmacokinetic study on multiple components of traditional Chinese medicine].

作者信息

Han Ling

机构信息

Center for Drug Evaluation, State Food and Drug Administration, Beijing 100038, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2008 Nov;33(21):2442-8.

Abstract

Facing the current situation, the paper reviewed the specificity, difficulty and significance in studying the pharmacokinetics of the multiple components of traditional Chinese medicine. Some key points in present pharmacokinetic study were also analyzed respectively in this paper, including the pharmacokinetic patterns of the individual herb, the prescription and its active fraction traditional Chinese medicine, the mechanism underlying the integrative effect of traditional Chinese medicinal prescription, the interaction between traditional Chinese medicine and chemical drug, and also the different pharmacokinetic patterns in the pathological situations of "Zheng" in traditional Chinese medicine and disease in modern medicine and the differences caused by different drug preparations. In addition, some viewpoints and suggestions were also given together with the consideration of "The basic technical requirements for the injections of traditional Chinese medicine and natural medicine".

摘要

面对当前形势,本文回顾了研究中药多成分药代动力学的特殊性、难点及意义。本文还分别分析了当前药代动力学研究中的一些关键点,包括单味中药、方剂及其活性部位的药代动力学特征,中药复方整合效应的机制,中药与化学药物的相互作用,以及中医“证”与现代医学疾病病理状态下不同的药代动力学特征和不同药物制剂所造成的差异。此外,结合《中药、天然药物注射剂基本技术要求》的考量,还提出了一些观点和建议。

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