De Lima H, Rodríguez N, Feliciangeli M D, Barrios M A, Sosa A, Agrela I, Sánchez E, Lopez O
Instituto de Biomedicina, Universidad Central de Venezuela/Ministerio de Salud, Apartado 4043, Caracas 1010A, Venezuela.
Trans R Soc Trop Med Hyg. 2009 Jul;103(7):721-6. doi: 10.1016/j.trstmh.2008.11.019. Epub 2009 Jan 15.
This study reports cutaneous leishmaniasis (CL) caused by Leishmania chagasi/Le. infantum in Venezuela, with some atypical characteristics. Out of 63 cases of CL in the suburbs of Altagracia de Orituco, Guarico State, Venezuela, 30 presented clinical, parasitological, immunological and epidemiological features different from those of the classical CL known in the country. The initial lesion was small and nodular, which, if not treated, might progress to a superficial ulcer. No secondary infection was observed. The identification of the isolates was carried out by molecular techniques. Twelve species of phlebotomine sandflies were caught, the most abundant being Lutzomyia evansi and Lu. longipalpis s.l., known vectors of Le. chagasi/Le. infantum. The existence of Le. chagasi/Le. infantum and its vectors in an endemic area of CL has implications and we suggest that epidemiological studies should be carried out to obtain a clearer picture of the extent of this CL form in Venezuela.
本研究报告了委内瑞拉由恰加斯利什曼原虫/婴儿利什曼原虫引起的皮肤利什曼病（CL），具有一些非典型特征。在委内瑞拉瓜里科州阿尔塔格拉西亚·德奥里图科郊区的63例CL病例中，有30例呈现出与该国已知的经典CL不同的临床、寄生虫学、免疫学和流行病学特征。初始病变为小的结节状，若不治疗，可能进展为浅表溃疡。未观察到继发感染。通过分子技术对分离株进行鉴定。捕获了12种白蛉，其中最常见的是伊凡斯罗蛉和长须罗蛉复合种，它们是恰加斯利什曼原虫/婴儿利什曼原虫的已知传播媒介。在CL流行地区存在恰加斯利什曼原虫/婴儿利什曼原虫及其传播媒介具有重要意义，我们建议应开展流行病学研究，以更清楚地了解委内瑞拉这种CL形式的流行程度。
