Fry Lionel, Baker Barbara S
Faculty of Medicine, Imperial College, St Mary's Campus, W2 1PG London, UK.
Clin Dermatol. 2007 Nov-Dec;25(6):606-15. doi: 10.1016/j.clindermatol.2007.08.015.
Psoriasis can be provoked or exacerbated by a variety of different environmental factors, particularly infections and drugs. Strong evidence exists for the induction of guttate psoriasis by a preceding tonsillar Streptococcus pyogenes infection, whereas disease exacerbation has been linked with skin and/or gut colonization by Staphylococcus aureus, Malassezia, and Candida albicans. The role, if any, of viruses (papillomaviruses, HIV, and endogenous retroviruses) present in lesional skin is at present unknown. The use of various drugs, such as lithium, beta-blockers, antimalarial agents, nonsteroidal anti-inflammatory drugs, and angiotensin-converting enzyme inhibitors, has also been associated with induction or worsening of disease in psoriatic patients.
银屑病可由多种不同的环境因素诱发或加重，尤其是感染和药物。有强有力的证据表明，先前的扁桃体化脓性链球菌感染可诱发点滴状银屑病，而疾病加重则与金黄色葡萄球菌、马拉色菌和白色念珠菌在皮肤和/或肠道的定植有关。目前尚不清楚皮损皮肤中存在的病毒（乳头瘤病毒、HIV和内源性逆转录病毒）的作用（如果有）。使用各种药物，如锂盐、β受体阻滞剂、抗疟药、非甾体抗炎药和血管紧张素转换酶抑制剂，也与银屑病患者疾病的诱发或恶化有关。
