核纤层蛋白与染色质：结构与功能的相遇 - Suppr

Suppr

超能文献

Nuclear lamins and chromatin: when structure meets function.

作者信息

Dechat Thomas, Adam Stephen A, Goldman Robert D

机构信息

Northwestern University Medical School, Department of Cell and Molecular Biology, Chicago, IL 60611, USA.

出版信息

Adv Enzyme Regul. 2009;49(1):157-66. doi: 10.1016/j.advenzreg.2008.12.003. Epub 2008 Dec 31.

DOI:10.1016/j.advenzreg.2008.12.003

PMID:19154754

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3253622/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9b4/3253622/2b758fcd59d2/nihms85567f1.jpg

相似文献

Nuclear lamins and chromatin: when structure meets function.核纤层蛋白与染色质：结构与功能的相遇

Adv Enzyme Regul. 2009;49(1):157-66. doi: 10.1016/j.advenzreg.2008.12.003. Epub 2008 Dec 31.

Nuclear lamins: key regulators of nuclear structure and activities.核纤层蛋白：核结构和核活动的关键调节因子。

J Cell Mol Med. 2009 Jun;13(6):1059-85. doi: 10.1111/j.1582-4934.2008.00676.x. Epub 2009 Feb 4.

Lamins: the structure and protein complexes.核纤层蛋白：结构与蛋白质复合体

Curr Opin Cell Biol. 2015 Feb;32:7-12. doi: 10.1016/j.ceb.2014.09.009. Epub 2014 Oct 13.

The nuclear lamins and the nuclear envelope.核纤层蛋白与核膜。

Cell Mol Biol Lett. 2002;7(4):1019-35.

Closing the (nuclear) envelope on the genome: how nuclear lamins interact with promoters and modulate gene expression.关闭基因组的（核）信封：核纤层如何与启动子相互作用并调节基因表达。

Bioessays. 2014 Jan;36(1):75-83. doi: 10.1002/bies.201300138. Epub 2013 Nov 24.

Linkage of lamins to fidelity of gene transcription.核纤层蛋白与基因转录保真度的关联。

Crit Rev Eukaryot Gene Expr. 2005;15(4):277-94. doi: 10.1615/critreveukargeneexpr.v15.i4.10.

To be or not be (in the LAD): emerging roles of lamin proteins in transcriptional regulation.成为或不成为（在 LAD 中）：层粘连蛋白在转录调控中的新兴作用。

Biochem Soc Trans. 2022 Apr 29;50(2):1035-1044. doi: 10.1042/BST20210858.

Lamins and chromatin join forces.核纤层蛋白与染色质协同作用。

Adv Biol Regul. 2025 Jan;95:101059. doi: 10.1016/j.jbior.2024.101059. Epub 2024 Nov 9.

Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation.核纤层蛋白：细胞核力学和基因组调控的基本功能的核中间丝蛋白。

Annu Rev Biochem. 2015;84:131-64. doi: 10.1146/annurev-biochem-060614-034115. Epub 2015 Feb 26.

LEM-Domain proteins: new insights into lamin-interacting proteins.LEM结构域蛋白：对核纤层相互作用蛋白的新见解

Int Rev Cytol. 2007;261:1-46. doi: 10.1016/S0074-7696(07)61001-8.

引用本文的文献

Genotoxic consequences of viral infections.病毒感染的遗传毒性后果。

Npj Viruses. 2025 Jan 27;3(1):5. doi: 10.1038/s44298-024-00087-5.

A novel role for CSA in the regulation of nuclear envelope integrity: uncovering a non-canonical function.CSA 在核膜完整性调控中的新作用：揭示一种非经典功能。

Life Sci Alliance. 2024 Aug 29;7(11). doi: 10.26508/lsa.202402745. Print 2024 Nov.

Genetic and Pathophysiological Basis of Cardiac and Skeletal Muscle Laminopathies.心脏和骨骼肌层状结构病的遗传和病理生理学基础。

Genes (Basel). 2024 Aug 20;15(8):1095. doi: 10.3390/genes15081095.

Nucleus Mechanosensing in Cardiomyocytes.心肌细胞中的核机械感知。

Int J Mol Sci. 2023 Aug 28;24(17):13341. doi: 10.3390/ijms241713341.

Histone Modification of Osteogenesis Related Genes Triggered by Substrate Topography Promotes Human Mesenchymal Stem Cell Differentiation.基质形貌引发的成骨相关基因的组蛋白修饰促进人骨髓间充质干细胞分化。

ACS Appl Mater Interfaces. 2023 Jun 28;15(25):29752-29766. doi: 10.1021/acsami.3c01481. Epub 2023 Jun 13.

ATXN3 controls DNA replication and transcription by regulating chromatin structure.ATXN3 通过调节染色质结构控制 DNA 复制和转录。

Nucleic Acids Res. 2023 Jun 23;51(11):5396-5413. doi: 10.1093/nar/gkad212.

Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations.软骨细胞去分化：核改变的生物物理线索。

Cells. 2022 Dec 12;11(24):4011. doi: 10.3390/cells11244011.

Confined migration induces heterochromatin formation and alters chromatin accessibility.受限迁移诱导异染色质形成并改变染色质可及性。

iScience. 2022 Aug 17;25(9):104978. doi: 10.1016/j.isci.2022.104978. eCollection 2022 Sep 16.

The BAF A12T mutation disrupts lamin A/C interaction, impairing robust repair of nuclear envelope ruptures in Nestor-Guillermo progeria syndrome cells.BAF A12T 突变破坏了核纤层蛋白 A/C 的相互作用，导致 Nestor-Guillermo 早衰综合征细胞中核膜破裂的强大修复受损。

Nucleic Acids Res. 2022 Sep 9;50(16):9260-9278. doi: 10.1093/nar/gkac726.

The Role of Lamins in the Nucleoplasmic Reticulum, a Pleiomorphic Organelle That Enhances Nucleo-Cytoplasmic Interplay.核纤层蛋白在核质网中的作用，核质网是一种可增强核质相互作用的多形性细胞器。

Front Cell Dev Biol. 2022 Jun 16;10:914286. doi: 10.3389/fcell.2022.914286. eCollection 2022.

本文引用的文献

The impact of gene location in the nucleus on transcriptional regulation.基因在细胞核中的位置对转录调控的影响。

Dev Cell. 2008 Aug;15(2):182-6. doi: 10.1016/j.devcel.2008.07.013.

Role of nuclear lamins in nuclear organization, cellular signaling, and inherited diseases.核纤层蛋白在细胞核组织、细胞信号传导及遗传性疾病中的作用。

Int Rev Cell Mol Biol. 2008;266:157-206. doi: 10.1016/S1937-6448(07)66004-3.

Nuclear shape, mechanics, and mechanotransduction.细胞核形态、力学及力传导

Circ Res. 2008 Jun 6;102(11):1307-18. doi: 10.1161/CIRCRESAHA.108.173989.

Role for A-type lamins in herpesviral DNA targeting and heterochromatin modulation.A型核纤层蛋白在疱疹病毒DNA靶向定位和异染色质调节中的作用。

PLoS Pathog. 2008 May 23;4(5):e1000071. doi: 10.1371/journal.ppat.1000071.

Scaffold/matrix attachment regions (S/MARs): relevance for disease and therapy.支架/基质附着区域（S/MARs）：与疾病和治疗的相关性

Handb Exp Pharmacol. 2008(186):67-103. doi: 10.1007/978-3-540-72843-6_4.

The nuclear envelope as an integrator of nuclear and cytoplasmic architecture.作为细胞核与细胞质结构整合体的核膜

FEBS Lett. 2008 Jun 18;582(14):2023-32. doi: 10.1016/j.febslet.2008.05.001. Epub 2008 May 12.

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions.通过核纤层相互作用图谱揭示的人类染色体结构域组织

Nature. 2008 Jun 12;453(7197):948-51. doi: 10.1038/nature06947. Epub 2008 May 7.

Nuclear functions in space and time: gene expression in a dynamic, constrained environment.细胞核在空间和时间上的功能：在动态、受限环境中的基因表达。

FEBS Lett. 2008 Jun 18;582(14):1960-70. doi: 10.1016/j.febslet.2008.04.029. Epub 2008 Apr 28.

Chromatin organization in relation to the nuclear periphery.与核周相关的染色质组织

FEBS Lett. 2008 Jun 18;582(14):2017-22. doi: 10.1016/j.febslet.2008.04.015. Epub 2008 Apr 22.

The highly conserved nuclear lamin Ig-fold binds to PCNA: its role in DNA replication.高度保守的核纤层蛋白免疫球蛋白折叠结构域与增殖细胞核抗原结合：其在DNA复制中的作用。

J Cell Biol. 2008 Apr 21;181(2):269-80. doi: 10.1083/jcb.200708155.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验