视神经脊髓炎中的白质光谱分析：一项病例对照研究。
White matter spectroscopy in neuromyelitis optica: a case control study.
作者信息
Bichuetti Denis Bernardi, Rivero René Leandro Magalhães, de Oliveira Enedina Maria Lobato, Oliveira Daniel May, de Souza Nilton Amorin, Nogueira Roberto Gomes, Abdala Nitamar, Gabbai Alberto
机构信息
Dept. of Neurology and Neurosurgery, Federal University of São Paulo (UNIFESP), Rua Pedro de Toledo 377, São Paulo, SP, Brazil.
出版信息
J Neurol. 2008 Dec;255(12):1895-9. doi: 10.1007/s00415-009-0940-0. Epub 2009 Jan 22.
BACKGROUND
Naa/Cr ratio in normal appearing white matter (NAWM) of patients with multiple sclerosis (MS) is altered beyond plaques, suggesting early axonal loss, and correlates to clinical disability. Brain lesions not typical of MS have been described in Neuromyelitis optica (NMO), and correspond to brain aquaporin-4 channel sites, but the evaluation of Naa/Cr ratio in NAWM of patients with NMO and its association to the presence of brain lesions and clinical disability have not been described.
OBJECTIVES
To evaluate the Naa/Cr of normal appearing white matter (NAWM) in 16 patients with NMO compared to healthy controls.
METHODS
We performed brain magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) of 16 patients with NMO and compared to age matched healthy controls.
RESULTS
NAWM Naa/Cr did not show statistical difference among patients and controls, neither between patients that had normal brain MRI and atypical brain lesions.
CONCLUSION
NAWM was found to have a normal Naa/Cr in patients with NMO, reinforcing the concept that the white matter is not primarily affected in this disease.
背景
多发性硬化症（MS）患者正常外观白质（NAWM）中的Naa/Cr比值在斑块外发生改变，提示早期轴突丢失，且与临床残疾相关。视神经脊髓炎（NMO）中已描述了非典型MS的脑病变，且与脑水通道蛋白-4通道位点相对应，但尚未描述NMO患者NAWM中Naa/Cr比值的评估及其与脑病变和临床残疾的关系。
目的
评估16例NMO患者与健康对照相比，正常外观白质（NAWM）的Naa/Cr情况。
方法
我们对16例NMO患者进行了脑磁共振成像（MRI）和磁共振波谱（MRS）检查，并与年龄匹配的健康对照进行比较。
结果
患者与对照之间，以及脑MRI正常和有非典型脑病变的患者之间，NAWM的Naa/Cr均无统计学差异。
结论
发现NMO患者的NAWM中Naa/Cr正常，强化了白质在该疾病中并非主要受累的概念。
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