Eusufzai S, Ericsson S, Cederlund T, Einarsson K, Angelin B
Metabolism Unit, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden.
Gut. 1991 Sep;32(9):1044-8. doi: 10.1136/gut.32.9.1044.
The effects of urodeoxycholic acid on ileal absorption of bile acids and on serum bile acid and lipoprotein concentrations were studied. Eight healthy subjects were investigated. The gamma emitting bile acid analogue, SeHCAT, was given orally and its fractional catabolic rate and seven day retention were assessed by repeated external counting over the upper abdomen during the next seven days. Ursodeoxycholic acid was then given orally at a dose of 15 mg/kg/day for three weeks and the study was repeated during treatment. The fractional catabolic rate increased by 64% (mean (SD), 0.333 (0.159) v 0.203 (0.061)/day; p less than 0.05) and seven day retention decreased by 44% (15(10) v 27(10)%, p less than 0.001), indicating bile acid malabsorption. Total serum cholesterol fell from 5.79 (1.22) to 5.50 (1.18) mmol/l (p = 0.05), while serum ursodeoxycholic acid increased 22 fold (7.87 (2.67) v 0.34 (0.24) mumol/l, p less than 0.001). Five of the subjects continued taking 30 mg/kg/day of ursodeoxycholic acid for one week and showed an increase in fractional catabolic rate of 81% (0.300 (0.091) v 0.166 (0.037)/day; p less than 0.05) and a fall in seven day retention of 50% (16 (12) v 32 (8)%, p less than 0.01). There were significant reductions in total cholesterol (5.36 (1.71) v 6.08 (1.47) mmol/l; p less than 0.05) and low density lipoprotein cholesterol (3.70 (1.33) v 4.58 (1.16) mmol/l; p less than 0.05). The results support the concept tht ursodeoxycholic acid treatment interferes with the absorption of endogenous bile acids, and emphasise the beneficial effects of this treatment of lipoprotein concentrations in man.
研究了熊去氧胆酸对回肠胆汁酸吸收以及血清胆汁酸和脂蛋白浓度的影响。对8名健康受试者进行了调查。口服γ发射型胆汁酸类似物SeHCAT，并在接下来的7天内通过对上腹部进行反复外部计数来评估其分解代谢率和7天潴留率。然后口服熊去氧胆酸，剂量为15mg/kg/天，持续3周，并在治疗期间重复该研究。分解代谢率增加了64%（均值（标准差），0.333（0.159）对0.203（0.061）/天；p<0.05），7天潴留率下降了44%（15（10）对27（10）%，p<0.001），表明胆汁酸吸收不良。血清总胆固醇从5.79（1.22）降至5.50（1.18）mmol/l（p=0.05），而血清熊去氧胆酸增加了22倍（7.87（2.67）对0.34（0.24）μmol/l，p<0.001）。5名受试者继续服用30mg/kg/天的熊去氧胆酸1周，分解代谢率增加了81%（0.300（0.091）对0.166（0.037）/天；p<0.05），7天潴留率下降了50%（16（12）对32（8）%，p<0.01）。总胆固醇（5.36（1.71）对6.08（1.47）mmol/l；p<0.05）和低密度脂蛋白胆固醇（3.70（1.33）对4.58（1.16）mmol/l；p<0.05）有显著降低。结果支持熊去氧胆酸治疗会干扰内源性胆汁酸吸收的概念，并强调了这种治疗对人体脂蛋白浓度的有益作用。 （注：原文中“tht”应改为“that”）
