Nishizumi M, Masuda Y
Cancer Lett. 1986 Dec;33(3):333-9. doi: 10.1016/0304-3835(86)90073-x.
Enhancement of diethylnitrosamine(DENA)-induced hepatic tumor production in rats was observed by sequential exposure to 2,3,4,7,8-pentachlorodibenzofuran (PenCDF) or 1,2,3,4,7,8-hexachlorodibenzofuran (HCDF). This effect was more evident in the group of rats treated with 2,3,4,7,8-PenCDF (80 micrograms/rat), in which approximately 43% of this compound administered was accumulated in the liver at 8 weeks after the last treatment.
通过连续暴露于2,3,4,7,8 - 五氯二苯并呋喃（PenCDF）或1,2,3,4,7,8 - 六氯二苯并呋喃（HCDF），观察到二乙基亚硝胺（DENA）诱导的大鼠肝肿瘤发生率增加。在用2,3,4,7,8 - PenCDF（80微克/只大鼠）处理的大鼠组中，这种效应更为明显，在最后一次处理后8周，所给予的该化合物约43%在肝脏中蓄积。
