McCutcheon Vivia V, Heath Andrew C, Edenberg Howard J, Grucza Richard A, Hesselbrock Victor M, Kramer John R, Bierut Laura Jean, Bucholz Kathleen K
Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8134, St. Louis, MO 63110-1010, United States.
Addict Behav. 2009 May;34(5):432-9. doi: 10.1016/j.addbeh.2008.12.003. Epub 2008 Dec 24.
Data from the Collaborative Study on the Genetics of Alcoholism (COGA), a high-risk family study of alcohol dependence, were used to examine differences in alcohol diagnostic criteria endorsement and psychiatric and drug use disorders by gender and by number of DUI offenses.
Individuals with two or more DUIs exhibited greater severity of alcohol dependence than those with none or one DUI. This severity was characterized in three ways: (1) higher endorsement of alcohol diagnostic criterion items, with evidence of greater severity among women, (2) higher prevalence of co-occurring lifetime psychiatric disorders, and (3) higher rates of drug use and of dependence on cocaine, stimulants, and, for women only, marijuana and opiates.
By examining gradations of disorder within a combination of two high-risk indicators, DUI and family vulnerability, this study provides useful information for clinical research about individuals with chronic and severe alcohol problems. In addition, the observed gender differences in this high-risk sample will contribute to the literature on alcohol dependence among women at the more severe end of the dependence spectrum.
酒精中毒遗传学合作研究(COGA)是一项针对酒精依赖的高危家庭研究,其数据被用于检验酒精诊断标准认可情况以及按性别和酒驾犯罪次数划分的精神疾病和药物使用障碍的差异。
有两次或更多次酒驾的个体比没有酒驾或只有一次酒驾的个体表现出更严重的酒精依赖。这种严重程度体现在三个方面:(1)对酒精诊断标准项目的认可度更高,且女性中的严重程度证据更明显;(2)共病终生精神疾病的患病率更高;(3)药物使用以及对可卡因、兴奋剂的依赖率更高,仅女性对大麻和阿片类药物的依赖率更高。
通过在酒驾和家族易感性这两个高危指标的组合中考察疾病的不同程度,本研究为关于患有慢性和严重酒精问题个体的临床研究提供了有用信息。此外,在这个高危样本中观察到的性别差异将为处于依赖谱更严重一端的女性酒精依赖文献做出贡献。