Vestbo J, Knudsen K M, Rasmussen F V
Medical Department P, Bispebjerg Hospital, Copenhagen, Denmark.
Int J Epidemiol. 1991 Jun;20(2):375-8. doi: 10.1093/ije/20.2.375.
The relationship between respiratory symptoms, chronic airflow limitation and respiratory cancer was examined in a random population sample of 876 middle-aged men. All men were examined in 1974 with interview and lung function tests. Information on respiratory cancer from 1974 to June 1985 was obtained from the Danish Cancer Register. Using a multivariate Cox regression model including age as the underlying time scale and controlling for pack-years of cigarettes, cough and breathlessness were found to be significantly related to cancer--relative risks (RRs) 2.5 (95% confidence interval (CI): 1.3-5.0) and 2.2 (95% CI: 1.0-4.9), respectively. Phlegm, chronic phlegm, and chronic bronchitis were not related to respiratory cancer after controlling for age and smoking. Forced expiratory volume in one second (FEV1) was related to respiratory cancer, RR = 2.1 (95% CI: 1.3-3.4) per litre under the expected FEV1 given height. Thus, our study demonstrates some relationship between respiratory symptoms and FEV1 and respiratory cancer; however, the study at the same time questions the previously demonstrated relationship between phlegm and respiratory cancer.
在一个由876名中年男性组成的随机人群样本中，研究了呼吸道症状、慢性气流受限与呼吸道癌症之间的关系。所有男性在1974年接受了访谈和肺功能测试。1974年至1985年6月期间的呼吸道癌症信息来自丹麦癌症登记处。使用以年龄为基本时间尺度的多变量Cox回归模型，并对吸烟包年数进行控制，发现咳嗽和呼吸急促与癌症显著相关——相对风险（RRs）分别为2.5（95%置信区间（CI）：1.3 - 5.0）和2.2（95% CI：1.0 - 4.9）。在控制年龄和吸烟因素后，咳痰、慢性咳痰和慢性支气管炎与呼吸道癌症无关。一秒用力呼气量（FEV1）与呼吸道癌症有关，在根据身高预期的FEV1每升下降的情况下，RR = 2.1（95% CI：1.3 - 3.4）。因此，我们的研究表明呼吸道症状和FEV1与呼吸道癌症之间存在一定关系；然而，该研究同时对之前所证明的咳痰与呼吸道癌症之间的关系提出了质疑。
