Thermes F, Molon-Noblot S, Grove J
Centre de Recherche, Merck Sharp & Dohme-Chibret, Riom, France.
Invest Ophthalmol Vis Sci. 1991 Oct;32(11):2958-63.
Conjunctival and corneal epithelial surfaces of normal rabbit eyes with their associated mucus were studied by scanning electron microscopy before and after treatment with the mucolytic agent N-acetylcysteine (AC). Four groups received topically one 50-microliters drop of either (Group A) 0.1 MAC, (Group B) 0.1 M AC every 5 min for 1 hr, (Group C) 0.1 M AC every 5 min for 2 hr, or (Group D) three drops of 20% AC over 15 min. The effects of the instillation of AC on mucus removal and cellular lesions increased in the order (A) less than (B) less than (C) less than (D). Treatment A had no effect on cornea and conjunctiva. Treatment B cleaned away mucosal debris without alteration of either conjunctival or corneal epithelium. Treatment C had a similar effect on the mucus but was associated with focal necrosis, and treatment D produced widespread necrosis, desquamation of epithelial cells, and inflammation.
在用黏液溶解剂N - 乙酰半胱氨酸（AC）处理之前和之后，通过扫描电子显微镜对正常兔眼的结膜和角膜上皮表面及其相关黏液进行了研究。四组分别局部滴入一滴50微升的以下溶液：（A组）0.1M的AC，（B组）每5分钟滴入0.1M的AC，持续1小时，（C组）每5分钟滴入0.1M的AC，持续2小时，或（D组）在15分钟内滴入三滴20%的AC。AC滴入对黏液清除和细胞损伤的影响按以下顺序增加：（A）＜（B）＜（C）＜（D）。A组处理对角膜和结膜无影响。B组处理清除了黏膜碎片，结膜和角膜上皮均无改变。C组处理对黏液有类似作用，但伴有局灶性坏死，而D组处理导致广泛坏死、上皮细胞脱落和炎症。
