微小RNA的进展：对免疫和炎症性疾病的影响

Sonkoly E, Pivarcsi A

Department of Medicine, Unit of Dermatology and Venerology, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

J Cell Mol Med. 2009 Jan;13(1):24-38. doi: 10.1111/j.1582-4934.2008.00534.x.

Since their discovery in 1993 and the introduction of the term microRNA in 2001, it has become evident that microRNAs (miRNAs) involved in many biological processes, including development, differentiation, proliferation and apoptosis. The function of miRNA the control of protein production in cells by sequence-specific targeting of mRNAs for translational repression or mRNA degradati Interestingly, immune genes are apparently preferentially targeted by miRNAs compared to the average of the human genome, indicat the significance of miRNA-mediated regulation for normal immune responses. Here, we review what is known about the role of miRN in the pathogenesis of immune-related diseases such as chronic inflammatory skin diseases, autoimmunity and viral infections.

自1993年发现并于2001年引入“微小RNA”这一术语以来，很明显微小RNA（miRNA）参与了许多生物学过程，包括发育、分化、增殖和凋亡。miRNA的功能是通过对mRNA进行序列特异性靶向以抑制翻译或降解mRNA来控制细胞中的蛋白质产生。有趣的是，与人类基因组的平均水平相比，免疫基因显然更易被miRNA靶向，这表明miRNA介导的调控对正常免疫反应具有重要意义。在这里，我们综述了关于miRNA在免疫相关疾病（如慢性炎症性皮肤病、自身免疫和病毒感染）发病机制中的作用的已知信息。