Division of Rheumatology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1670, USA.
Autoimmun Rev. 2013 Oct;12(12):1160-5. doi: 10.1016/j.autrev.2013.07.003. Epub 2013 Jul 14.
miRNAs are small non-coding RNA molecules that modulate the expression of multiple protein-encoding genes at the post-transcriptional level. They have recently been recognized as powerful regulators of numerous genes and pathways in the pathogenesis of inflammatory and autoimmune diseases. The targets of most miRNAs remain unknown and their roles in biological processes such as cell differentiation, proliferation, and death (apoptosis) are not clearly understood. In this review we will discuss how certain candidate miRNAs affect inflammatory and immune mediated diseases by regulating their cellular and molecular targets. We focused the influence of gender and sex hormones on miRNA. We believe that understanding the role of miRNAs could shed light on the cause and progression of many inflammatory and autoimmune diseases and eventually lay the groundwork for therapeutic options.
miRNAs 是一类小的非编码 RNA 分子，可在转录后水平调节多个蛋白质编码基因的表达。最近，它们被认为是炎症和自身免疫性疾病发病机制中许多基因和通路的强大调控因子。大多数 miRNA 的靶标仍然未知，其在细胞分化、增殖和死亡（细胞凋亡）等生物学过程中的作用也不清楚。在这篇综述中，我们将讨论某些候选 miRNA 通过调节其细胞和分子靶标如何影响炎症和免疫介导的疾病。我们重点讨论了性别和性激素对 miRNA 的影响。我们相信，了解 miRNA 的作用可以揭示许多炎症和自身免疫性疾病的病因和进展，并为治疗选择奠定基础。
