一种新型抗生素，奥基西酮。I. 分类学、发酵、分离及生物学特性。

A new antibiotic, okicenone. I. Taxonomy, fermentation, isolation and biological characteristics.

作者信息

Komiyama K, Funayama S, Anraku Y, Ishibashi M, Takahashi Y, Kawakami T, Omura S

机构信息

Kitasato Institute, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1991 Aug;44(8):814-8. doi: 10.7164/antibiotics.44.814.

DOI:10.7164/antibiotics.44.814

PMID:1917695

Abstract

A new antibiotic, okicenone was isolated from the culture broth of Streptomyces sp. KO-3599. The antibiotic possesses cytocidal activity against mammalian tumor cells in vitro at concentrations of 0.53-11.0 micrograms/ml whereas the antibiotic showed no antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi or yeast at a concentration of 1,000 micrograms/ml.

摘要

一种新的抗生素——奥基西农，是从链霉菌属KO-3599的培养液中分离出来的。该抗生素在体外对哺乳动物肿瘤细胞具有杀细胞活性，浓度为0.53 - 11.0微克/毫升，而在浓度为1000微克/毫升时，对革兰氏阳性菌、革兰氏阴性菌、真菌或酵母菌均无抗菌活性。