Komiyama K, Otoguro K, Segawa T, Shiomi K, Yang H, Takahashi Y, Hayashi M, Otani T, Omura S
Kitasato Institute, Tokyo, Japan.
J Antibiot (Tokyo). 1993 Nov;46(11):1666-71. doi: 10.7164/antibiotics.46.1666.
A new peptide antibiotic, cypemycin, with a molecular weight of 2,097 (M+H), was isolated from the culture broth of Streptomyces sp. OH-4156. The antibiotic possesses cytocidal activity against P388 leukemia cells in vitro at a concentration of 1.3 microgram/ml (IC50 values), and the antibiotic showed antimicrobial activities against Micrococcus luteus (MIC, 0.2 microgram/ml).
一种新的肽抗生素——环霉素，分子量为2,097（M+H），是从链霉菌属OH-4156菌株的培养液中分离得到的。该抗生素在体外对P388白血病细胞具有杀细胞活性，浓度为1.3微克/毫升（IC50值），并且对藤黄微球菌具有抗菌活性（MIC，0.2微克/毫升）。
