Miller Douglas K, Malmstrom Theodore K, Andresen Elena M, Miller J Philip, Herning Margaret M, Schootman Mario, Wolinsky Fredric D
Center for Aging Research, Indiana University, Indianapolis, IN 46202, USA.
J Gerontol A Biol Sci Med Sci. 2009 Mar;64(3):388-94. doi: 10.1093/gerona/gln033. Epub 2009 Jan 30.
Poor muscle size and function (sarcopenia) have an important role in the age-associated disability process. However, no commonly accepted index of sarcopenia exists for use in epidemiological studies.
A cohort of 998 community-dwelling African Americans 49-65 years' old at baseline was used to construct the short portable sarcopenia measure (SPSM). SPSM was conceptualized as a measure of sarcopenia that combines estimates of muscle quantity and function into a single scale, is based on component items that can be obtained easily in the field, represents muscle status at a single time point that can be used without sex-specific adjustments, and can be used to follow change in muscle status over time with each person as his or her own control. We used exploratory factor analysis (EFA) to identify a unidimensional scale based on timed chair rises, lean mass, and grip strength divided by height. We used these three items and their EFA factor weights to construct SPSM (mean 9.0, median 9, range 0 [worst] to 18 [best] at baseline). Construct validity of the new measure, over a period of 36 months was examined.
SPSM required 8.5 pounds of equipment and 12.4 minutes to complete. It showed good score distribution and convergent, discriminant, and predictive validity with measures of muscle function, body composition, physical performance, psychological factors, and functional limitation cross-sectionally and with muscle function and body composition longitudinally. Extensive sensitivity analyses confirmed SPSM's robustness.
SPSM is a brief, portable, and valid measure of sarcopenia for use in epidemiological research. Similar studies in other populations are needed.
肌肉量减少和功能减退（肌肉减少症）在与年龄相关的残疾过程中起重要作用。然而，目前尚无用于流行病学研究的被广泛接受的肌肉减少症指标。
以一个由998名基线时年龄在49 - 65岁的非裔美国社区居民组成的队列构建简易便携式肌肉减少症测量方法（SPSM）。SPSM被概念化为一种肌肉减少症测量方法，它将肌肉量和功能的评估整合到一个单一量表中，基于可在现场轻松获取的组成项目，代表单个时间点的肌肉状态，无需进行性别特异性调整即可使用，并且可用于追踪每个人随时间的肌肉状态变化，以自身作为对照。我们使用探索性因子分析（EFA）基于定时从椅子上起身、瘦体重以及握力除以身高来确定一个单维量表。我们使用这三个项目及其EFA因子权重来构建SPSM（基线时均值为9.0，中位数为9，范围为0[最差]至18[最佳]）。对新测量方法在36个月期间的结构效度进行了检验。
SPSM需要8.5磅设备，完成时间为12.4分钟。它显示出良好的分数分布，并且在横断面以及纵向与肌肉功能、身体成分、身体表现、心理因素和功能受限的测量指标具有收敛效度、判别效度和预测效度。广泛的敏感性分析证实了SPSM的稳健性。
SPSM是一种用于流行病学研究的简易、便携式且有效的肌肉减少症测量方法。需要在其他人群中开展类似研究。
