Felzmann T, Gadd S, Majdic O, Maurer D, Petera P, Smolen J, Knapp W
Institute of Immunology, University of Vienna, Austria.
J Clin Immunol. 1991 Jul;11(4):205-12. doi: 10.1007/BF00917426.
In this study we report the expression pattern of 13 different function-associated surface molecules on synovial fluid and peripheral blood granulocytes from rheumatoid and reactive arthritis patients. We found increased expression of the complement receptors 1 (CD35) and 3 (CD11b) and of the activation-associated antigens CD67, CD24, and M5 on synovial fluid granulocytes from rheumatoid and/or reactive arthritis patients compared to autologous peripheral blood granulocytes. In addition, synovial fluid granulocytes expressed IgG Fc receptor 1 (CD64) and complement receptor 4 (CD11c), neither of which can be found on peripheral blood granulocytes. Peripheral blood granulocytes from rheumatoid and reactive arthritis patients expressed higher levels of leucocyte function-associated antigen 1 (CD11a) and of the membrane proteins CD31, CD24, M5, and M6 compared to peripheral blood granulocytes from healthy controls and patients with degenerative joint disease. No significant differences in the expression of any of the molecules studied could be observed between cells from rheumatoid and cells from reactive arthritis patients, suggesting a similar activation process for granulocytes in these two diseases.
在本研究中，我们报告了类风湿性关节炎和反应性关节炎患者滑液及外周血粒细胞上13种不同功能相关表面分子的表达模式。我们发现，与自体外周血粒细胞相比，类风湿性关节炎和/或反应性关节炎患者滑液粒细胞上补体受体1（CD35）和3（CD11b）以及活化相关抗原CD67、CD24和M5的表达增加。此外，滑液粒细胞表达IgG Fc受体1（CD64）和补体受体4（CD11c），而外周血粒细胞上均未发现。与健康对照和退行性关节病患者的外周血粒细胞相比，类风湿性关节炎和反应性关节炎患者的外周血粒细胞表达更高水平的白细胞功能相关抗原1（CD11a）以及膜蛋白CD31、CD24、M5和M6。在类风湿性关节炎患者的细胞和反应性关节炎患者的细胞之间，未观察到所研究的任何分子表达有显著差异，这表明这两种疾病中粒细胞的活化过程相似。
