Gadd S J, Felzmann T, Majdic O, Maurer D, Petera P, Chen W J, Smolen J, Knapp W
Institute of Immunology, University of Vienna, Austria.
Rheumatol Int. 1992;12(4):153-7. doi: 10.1007/BF00274935.
Surface expression of 16 different membrane molecules was analyzed in peripheral blood and synovial fluid monocytes from patients with rheumatoid arthritis and reactive arthritis compared to controls. The most significant findings were modulated expression of function-associated FcRI, CR1, CR3, MHC class II and activation-associated CD31, M5, and M6 molecules in arthritis patients compared to controls. Of these molecules, only upregulated expression of MHC class II has previously been reported in synovial fluid monocytes of patients with rheumatoid arthritis.
与对照组相比，分析了类风湿性关节炎和反应性关节炎患者外周血和滑液单核细胞中16种不同膜分子的表面表达。最显著的发现是，与对照组相比，关节炎患者中功能相关的FcRI、CR1、CR3、MHC II类分子以及激活相关的CD31、M5和M6分子的表达受到调节。在这些分子中，此前仅报道过类风湿性关节炎患者滑液单核细胞中MHC II类分子的表达上调。
