Lee Meeyoung, Kim Soyoung, Kwon Ok-Kyoung, Oh Sei-Ryang, Lee Hyeong-Kyu, Ahn Kyungseop
Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusung, Daejeon, Korea.
Int Immunopharmacol. 2009 Apr;9(4):418-24. doi: 10.1016/j.intimp.2009.01.005. Epub 2009 Feb 8.
Asthma is an inflammatory disease of the airways, and the current focus in managing asthma is the control of inflammation. Resveratrol (3,4,5-trihydroxystilbene) is a polyphenolic stilbene found in the skins of red fruits, including grapes, that may be responsible for some of the health benefits ascribed to consumption of red wine. We investigated the suppressive effects of resveratrol on asthmatic parameters such as cytokine release, eosinophilia, airway hyperresponsiveness, and mucus hypersecretion, in an OVA-induced allergic mouse model of asthma. Resveratrol significantly inhibited increases in T-helper-2-type cytokines such as IL-4 and IL-5 in plasma and bronchoalveolar lavage fluid (BALF), and also effectively suppressed airway hyperresponsiveness, eosinophilia, and mucus hypersecretion, in the asthmatic mouse model. The efficacy of resveratrol was similar to that of dexamethasone, a glucocorticoid used as a positive control. These results suggest that resveratrol may have applications in the treatment of bronchial asthma.
哮喘是一种气道炎症性疾病，目前哮喘管理的重点是控制炎症。白藜芦醇（3,4,5 - 三羟基茋）是一种存在于包括葡萄在内的红色水果皮中的多酚类茋，它可能是饮用红酒带来某些健康益处的原因之一。我们在卵清蛋白诱导的哮喘过敏性小鼠模型中，研究了白藜芦醇对哮喘参数（如细胞因子释放、嗜酸性粒细胞增多、气道高反应性和黏液分泌过多）的抑制作用。在哮喘小鼠模型中，白藜芦醇显著抑制血浆和支气管肺泡灌洗液（BALF）中白细胞介素 - 4和白细胞介素 - 5等辅助性T细胞2型细胞因子的增加，还有效抑制了气道高反应性、嗜酸性粒细胞增多和黏液分泌过多。白藜芦醇的疗效与用作阳性对照的糖皮质激素地塞米松相似。这些结果表明白藜芦醇可能在支气管哮喘治疗中具有应用价值。
