Jardeleza Maria Stephanie R, Daly Mary K, Kaufman Jessica D, Klapperich Catherine, Legutko Paul A
Department of Ophthalmology, Veterans Affairs Boston Healthcare System Jamaica Plain, Boston, Massachusetts 02130-4893, USA.
J Cataract Refract Surg. 2009 Feb;35(2):318-23. doi: 10.1016/j.jcrs.2008.10.040.
To determine whether trypan blue causes a significant difference in the biomechanical properties (stiffness) of diabetic and nondiabetic anterior lens capsules and to determine whether diabetes significantly alters the stiffness of anterior lens capsules.
Veterans Administration Boston Healthcare Center System, Jamaica Plain, Massachusetts, USA.
In this unmasked prospective randomized controlled experimental study, anterior lens capsules were obtained from diabetic and nondiabetic patients approved for cataract surgery. Four treatment groups were created: (1) capsules of nondiabetic patients without trypan blue; capsules of nondiabetic patients with trypan blue; (3) capsules of diabetic patients without trypan blue; (4) capsules of diabetic patients with trypan blue. Anterior lens capsule stiffness as a function of elastic (Young's) modulus (kilopascals) was measured with the Hysitron TriboIndenter.
The use of trypan blue led to significantly stiffer anterior lens capsules (P= .036). Trypan blue had the greatest effect on the stiffness of diabetic lens capsules (P= .046).
Trypan blue contributed to increased capsule stiffness during capsulorhexis, especially in diabetic patients.
确定台盼蓝是否会使糖尿病患者和非糖尿病患者的前囊膜生物力学特性（硬度）产生显著差异，并确定糖尿病是否会显著改变前囊膜的硬度。
美国马萨诸塞州牙买加平原退伍军人事务部波士顿医疗中心系统。
在这项非盲前瞻性随机对照实验研究中，从批准进行白内障手术的糖尿病患者和非糖尿病患者获取前囊膜。创建了四个治疗组：（1）未使用台盼蓝的非糖尿病患者的囊膜；（2）使用台盼蓝的非糖尿病患者的囊膜；（3）未使用台盼蓝的糖尿病患者的囊膜；（4）使用台盼蓝的糖尿病患者的囊膜。使用Hysitron TriboIndenter测量前囊膜硬度作为弹性（杨氏）模量（千帕斯卡）的函数。
使用台盼蓝导致前囊膜硬度显著增加（P = 0.036）。台盼蓝对糖尿病患者囊膜的硬度影响最大（P = 0.046）。
台盼蓝在撕囊过程中导致囊膜硬度增加，尤其是在糖尿病患者中。
