Rassameemasmaung Supanee, Sirikulsathean Anongporn, Amornchat Cholticha, Maungmingsook Pawinee, Rojanapanthu Pleumchitt, Gritsanaphan Wandee
Department of Oral Medicine, Faculty of Dentistry, Mahidol University, Ratchathewi, Bangkok 10400, Thailand.
Complement Ther Med. 2008 Oct;16(5):262-7. doi: 10.1016/j.ctim.2007.12.004.
To evaluate the effects of gel containing Garcinia mangostana L. pericarp extract (GM gel) applied topically as an adjunct to periodontal treatment.
Subjects who had periodontal pockets on their single-rooted teeth were randomized into the test or control group. Subjects in the test group received periodontal treatment consisting of scaling, root planing and subgingival application of GM gel while those in the control group received scaling and root planing without GM gel application.
Mahidol University, Faculty of Dentistry, Thailand.
Clinical parameters included probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), Gingival Index (GI) and Plaque Index (PI). Microbiological parameter included subgingival microbial composition as examined by phase contrast microscopy.
Clinical improvement compared to baseline was found in both groups (P < 0.05). The test group exhibited significantly higher reduction in mean PPD, GI and BOP than the control group at the 3rd month after treatment (P < 0.05). Subgingival microbial composition changed from diseased state to that compatible with health after treatment in both groups. However, significant differences between groups were found only in the mean percentage of cocci at the 1st and 3rd month after treatment (P < 0.05).
GM gel could enhance the clinical effects of periodontal treatment.
评估局部应用含有山竹果皮提取物的凝胶（GM凝胶）作为牙周治疗辅助手段的效果。
将单根牙有牙周袋的受试者随机分为试验组或对照组。试验组受试者接受包括龈上洁治、根面平整及龈下应用GM凝胶的牙周治疗，而对照组受试者仅接受龈上洁治和根面平整，不应用GM凝胶。
泰国玛希隆大学牙科学院。
临床参数包括探诊深度（PPD）、临床附着水平（CAL）、探诊出血（BOP）、牙龈指数（GI）和菌斑指数（PI）。微生物学参数包括通过相差显微镜检查的龈下微生物组成。
两组与基线相比均有临床改善（P < 0.05）。治疗后第3个月，试验组的平均PPD、GI和BOP降低幅度显著高于对照组（P < 0.05）。两组治疗后龈下微生物组成均从患病状态转变为与健康状态相符。然而，仅在治疗后第1个月和第3个月，两组间球菌的平均百分比存在显著差异（P < 0.05）。
GM凝胶可增强牙周治疗的临床效果。
