ω-3脂肪酸可抑制SW620人结肠癌异种移植瘤在裸鼠体内的生长。
Omega-3 fatty acids suppress growth of SW620 human colon cancer xenografts in nude mice.
作者信息
Bathen Tone F, Holmgren Kristin, Lundemo Anne Gøril, Hjelstuen Mari H, Krokan Hans E, Gribbestad Ingrid S, Schønberg Svanhild A
机构信息
Department of Circulation and Medical Imaging, NTNU, N-7489 Trondheim, Norway.
出版信息
Anticancer Res. 2008 Nov-Dec;28(6A):3717-23.
AIM
The purpose of this study was to examine the influence of fish oil on growth of colon cancer in nude mice.
MATERIALS AND METHODS
Xenografts were initiated in mice receiving a standard diet or diets modified with corn or fish oil. After 3 weeks, mice were sacrificed, tumours were removed and processed for lipid analysis, histopathology and high resolution magic angle spinning magnetic resonance spectroscopy.
RESULTS
Diet modified with fish oil suppressed tumour growth. Xenografts from mice receiving fish oil had higher levels of omega-3 polyunsaturated fatty acids (PUFAs) with concomitant reduced levels of omega-6 PUFAs. Furthermore, these xenografts had significantly lower levels of phosphocholine. Overall the results indicated less aggressive tumour growth in mice receiving a fish oil diet.
目的
本研究旨在探讨鱼油对裸鼠结肠癌生长的影响。
材料与方法
在接受标准饮食或用玉米或鱼油改良饮食的小鼠中启动异种移植。3周后，处死小鼠，切除肿瘤并进行脂质分析、组织病理学和高分辨率魔角旋转磁共振波谱分析。
结果
用鱼油改良的饮食可抑制肿瘤生长。接受鱼油的小鼠的异种移植瘤中ω-3多不饱和脂肪酸（PUFAs）水平较高，同时ω-6 PUFAs水平降低。此外，这些异种移植瘤中的磷酸胆碱水平显著较低。总体结果表明，接受鱼油饮食的小鼠肿瘤生长不那么活跃。
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